STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1167Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (384 aa)    
Predicted Functional Partners:
STY1168
Putative secreted protein; Similar to Escherichia coli hypothetical 28.3 kda protein in feci-fimb intergenic region precursor yjha SW:YJHA_ECOLI (P39372) fasta scores: E(): 5.3e-10, 25.5% id in 243 aa.
  
  
 0.905
STY3519
Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
  
  
 0.878
STY3520
N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
  
  
 0.819
STY1166
Conserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
  
 0.790
STY1169
Putative transporter; Similar to Acinetobacter calcoaceticus cis,cis-muconate transport protein muck SW:MUCK_ACICA (P94131) fasta scores: E(): 4.1e-26, 28.8% id in 382 aa; Orthologue of E. coli yjhB (YJHB_ECOLI); Fasta hit to YJHB_ECOLI (405 aa), 57% identity in 406 aa overlap.
 
  
 0.777
STY1170
Putative oxidoreductase; Similar to Rhizobium meliloti myo-inositol 2-dehydrogenase idha SW:MI2D_RHIME (O68965) fasta scores: E(): 1.4e-14, 26.8% id in 370 aa; Orthologue of E. coli yjhC (YJHC_ECOLI); Fasta hit to YJHC_ECOLI (372 aa), 62% identity in 366 aa overlap.
 
   
 0.763
STY4851
Conserved hypothetical protein; Similar in N-terminus to, but longer than, Escherichia coli hypothetical 58.6 kDa protein in iada-mcrd intergenic region yjiT SW:YJIT_ECOLI (P39391) (521 aa) fasta scores: E(): 0, 58.1% id in 503 aa.
  
     0.734
pgtC
Phosphoglycerate transport regulatory protein PgtC precursor; Required for pgtP expression, it may act jointly with the PgtA/PgtB signaling proteins.
  
     0.723
pgtB
Similar to Salmonella typhimurium phosphoglycerate transport system sensor protein PgtB pgtB SW:PGTB_SALTY (P37433) (593 aa) fasta scores: E(): 0, 98.6% id in 513 aa, and to Vibrio cholerae putative phosphoglycerate transport regulatory protein pgtB, vca0705 TR:Q9KLN8 (EMBL:AE004400) (789 aa) fasta scores: E(): 1.4e-26, 25.0% id in 781 aa, and to Rhizobium leguminosarum c4-dicarboxylate transport sensor protein DctB dctB SW:DCTB_RHILE (P10047) (622 aa) fasta scores: E(): 2.7e-21, 35.1% id in 259 aa.
  
     0.718
STY4849
Helicase related protein; Possible helicase. Similar to Deinococcus radiodurans RNA helicase, putative DRB0135 TR:Q9RZJ2 (EMBL:AE001826) (1706 aa) fasta scores: E(): 5.6e-16, 24.4% id in 810 aa. C-terminal region of the protein is similar to the C-terminal region of Escherichia coli McrD protein SW:MCRD_ECOLI (P27301) (409 aa) fasta scores: E(): 0, 62.3% id in 273 aa. N-terminal region of the protein is similar to the N-terminal region of mcrD and to the C-terminus of Escherichia coli hypothetical 58.2 kDa protein in iadA-mcrD intergenic region YjiV SW:YJIV_ECOLI (P39393; P39392) (513 [...]
  
     0.680
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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