STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STY1172Putative 2-hydroxyacid dehydrogenase in phoh-csgg intergenic region; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)    
Predicted Functional Partners:
hyi
Glyoxylate-induced protein; Similar to Escherichia coli hydroxypyruvate isomerase hyi or giP SW:HYI_ECOLI (P30147) (258 aa) fasta scores: E(): 0, 84.1% id in 258 aa; Fasta hit to YGBM_ECOLI (258 aa), 39% identity in 258 aa overlap; Orthologue of E. coli gip (GIP_ECOLI); Fasta hit to GIP_ECOLI (258 aa), 84% identity in 258 aa overlap; Belongs to the hyi family.
  
 
  0.938
STY4156
Putative 2-hydroxyacid dehydrogenase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
 
  
0.919
garR
Similar to Escherichia coli 2-hydroxy-3-oxopropionate reductase garr or b3125 SW:GARR_ECOLI (P23523) (294 aa) fasta scores: E(): 0, 42.9% id in 289 aa; Fasta hit to YIHU_ECOLI (298 aa), 31% identity in 290 aa overlap; Fasta hit to YHAE_ECOLI (294 aa), 43% identity in 289 aa overlap; Orthologue of E. coli YBBQ_ECOLI; Fasta hit to YBBQ_ECOLI (292 aa), 91% identity in 292 aa overlap.
 
  
  0.916
gph
Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
    
 0.910
STY4402
Isocitrate lyase; Similar to Escherichia coli isocitrate lyase AceA SW:ACEA_ECOLI (P05313) (434 aa) fasta scores: E(): 0, 95.6% id in 434 aa, and to Vibrio cholerae isocitrate lyase VC0736 TR:Q9KTZ4 (EMBL:AE004159) (437 aa) fasta scores: E(): 0, 79.4% id in 433 aa.
   
 
 0.910
STY4401
Similar to Escherichia coli malate synthase A AceB SW:MASY_ECOLI (P08997) (533 aa) fasta scores: E(): 0, 90.8% id in 533 aa, and to Myxococcus xanthus malate synthase mls SW:MASY_MYXXA (P95329) (541 aa) fasta scores: E(): 0, 56.2% id in 511 aa.
     
 0.908
STY1687
Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
    
 0.902
STY1174
Conserved hypothetical protein; Orthologue of E. coli YCDY_ECOLI; Fasta hit to YCDY_ECOLI (184 aa), 86% identity in 184 aa overlap.
     
 0.901
garR-2
2-hydroxy-3-oxopropionate reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily.
    
  0.901
gcl
Similar to Escherichia coli glyoxylate carboligase SW:GCL_ECOLI () (592 aa) fasta scores: E(): 0, 95.8% id in 592 aa, and to Corynebacterium glutamicum acetolactate synthase large subunit ilvB SW:ILVB_CORGL (P42463) (626 aa) fasta scores: E(): 0, 37.8% id in 561 aa; Belongs to the TPP enzyme family.
     
 0.900
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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