STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1540Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site (By similarity). (125 aa)    
Predicted Functional Partners:
STY1541
Multiple antibiotic resistance protein MarA; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF (By similarity).
  
  
 0.994
STY0521
Potential acrAB operon repressor; Fasta hit to ENVR_ECOLI (220 aa), 38% identity in 203 aa overlap; Orthologue of E. coli acrR (ACRR_ECOLI); Fasta hit to ACRR_ECOLI (215 aa), 87% identity in 214 aa overlap.
      
 0.885
STY1542
Multiple antibiotic resistance protein MarB; Orthologue of E. coli marB (MARB_ECOLI); Fasta hit to MARB_ECOLI (72 aa), 47% identity in 71 aa overlap.
     
 0.813
soxR
SoxR protein; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
  
   
 0.807
slyA
Transcriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family.
      
 0.779
soxS
Regulatory protein SoxS; Orthologue of E. coli soxS (SOXS_ECOLI); Fasta hit to SOXS_ECOLI (106 aa), 94% identity in 106 aa overlap.
   
  
 0.775
STY0520
Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
     
 0.762
tolC
Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap.
     
 0.758
STY1539
Putative membrane protein; Fasta hit to YCHE_ECOLI (215 aa), 30% identity in 202 aa overlap; Orthologue of E. coli ydeB (MARC_ECOLI); Fasta hit to MARC_ECOLI (221 aa), 92% identity in 221 aa overlap.
     
 0.676
STY2941
Multidrug resistance protein B; Fasta hit to YIEO_ECOLI (475 aa), 33% identity in 424 aa overlap; Fasta hit to EMRY_ECOLI (512 aa), 63% identity in 506 aa overlap; Orthologue of E. coli emrB (EMRB_ECOLI); Fasta hit to EMRB_ECOLI (512 aa), 96% identity in 512 aa overlap; Belongs to the major facilitator superfamily.
 
  
 0.664
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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