STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STY1541Multiple antibiotic resistance protein MarA; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF (By similarity). (144 aa)    
Predicted Functional Partners:
STY1540
Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site (By similarity).
  
  
 0.994
STY0521
Potential acrAB operon repressor; Fasta hit to ENVR_ECOLI (220 aa), 38% identity in 203 aa overlap; Orthologue of E. coli acrR (ACRR_ECOLI); Fasta hit to ACRR_ECOLI (215 aa), 87% identity in 214 aa overlap.
  
   
 0.914
STY0520
Acriflavin resistance protein A precursor; Fasta hit to YHIU_ECOLI (385 aa), 54% identity in 391 aa overlap; Fasta hit to ACRE_ECOLI (385 aa), 67% identity in 388 aa overlap; Orthologue of E. coli acrA (ACRA_ECOLI); Fasta hit to ACRA_ECOLI (397 aa), 91% identity in 397 aa overlap; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
      
 0.878
tolC
Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap.
      
 0.854
STY1542
Multiple antibiotic resistance protein MarB; Orthologue of E. coli marB (MARB_ECOLI); Fasta hit to MARB_ECOLI (72 aa), 47% identity in 71 aa overlap.
  
  
 0.842
STY2719
Putative efflux pump; Similar to Pseudomonas aeruginosa multidrug resistance protein MexB mexB SW:MEXB_PSEAE (P52002) (1046 aa) fasta scores: E(): 0, 61.7% id in 1032 aa; Fasta hit to ACRF_ECOLI (1034 aa), 63% identity in 1032 aa overlap; Fasta hit to ACRB_ECOLI (1049 aa), 66% identity in 1036 aa overlap; Fasta hit to YHIV_ECOLI (1037 aa), 60% identity in 1032 aa overlap; Orthologue of E. coli acrD (ACRD_ECOLI); Fasta hit to ACRD_ECOLI (1037 aa), 94% identity in 1037 aa overlap.
    
 
 0.822
soxR
SoxR protein; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity).
  
   
 0.791
STY0519
Acriflavin resistance protein B; Fasta hit to ACRF_ECOLI (1034 aa), 78% identity in 1033 aa overlap; Fasta hit to YHIV_ECOLI (1037 aa), 71% identity in 1035 aa overlap; Fasta hit to ACRD_ECOLI (1037 aa), 65% identity in 1036 aa overlap; Orthologue of E. coli acrB (ACRB_ECOLI); Fasta hit to ACRB_ECOLI (1049 aa), 95% identity in 1048 aa overlap.
    
 
 0.764
STY1002
Outer membrane protein F precursor; Forms pores that allow passive diffusion of small molecules across the outer membrane; Belongs to the Gram-negative porin family.
      
 0.761
STY3824
L-rhamnose operon transcriptional activator; Activates expression of the rhaSR operon in response to L- rhamnose.
  
   0.759
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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