STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1661Conserved hypothetical protein; Binds to H-NS and modified the range of genes it silences; H- NS alonge silences core gene while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer. Plays a role silencing virulence factors in the absence of factors that induce pathogenicity (By similarity). The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC (By similarity); Belongs to the Hha/YmoA/Cnu family. (71 aa)    
Predicted Functional Partners:
STY2920
DNA-binding protein StpA; A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity).
  
 
 
 0.911
STY1662
Putative membrane protein; Orthologue of E. coli YDGK_ECOLI; Fasta hit to YDGK_ECOLI (146 aa), 83% identity in 146 aa overlap.
 
    0.887
STY1299
DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity).
  
 
 
 0.828
STY1590
Putative exported protein; Orthologue of E. coli YDGH_ECOLI; Fasta hit to YDGH_ECOLI (314 aa), 90% identity in 314 aa overlap.
  
   
 0.801
STY2082
DNA polymerase III, theta subunit; Orthologue of E. coli holE (HOLE_ECOLI); Fasta hit to HOLE_ECOLI (76 aa), 88% identity in 76 aa overlap.
  
     0.772
STY2157
Conserved hypothetical protein; Orthologue of E. coli yecF (YECF_ECOLI); Fasta hit to YECF_ECOLI (74 aa), 88% identity in 74 aa overlap.
  
     0.771
STY3542
Conserved hypothetical protein; Fasta hit to YCFR_ECOLI (85 aa), 34% identity in 88 aa overlap; Fasta hit to YJFN_ECOLI (100 aa), 34% identity in 93 aa overlap; Fasta hit to YAHO_ECOLI (91 aa), 31% identity in 91 aa overlap; Fasta hit to YJFY_ECOLI (91 aa), 33% identity in 87 aa overlap; Fasta hit to YBIJ_ECOLI (86 aa), 47% identity in 88 aa overlap; Orthologue of E. coli YHCN_ECOLI; Fasta hit to YHCN_ECOLI (87 aa), 78% identity in 87 aa overlap.
  
     0.770
STY2456
Conserved hypothetical protein; Orthologue of E. coli yejG (YEJG_ECOLI); Fasta hit to YEJG_ECOLI (114 aa), 90% identity in 114 aa overlap.
  
     0.769
STY3811
Extracytoplasmic stress protein for protein-mediated toxicities; Similar to Escherichia coli periplasmic protein CpxP precursor SW:CPXP_ECOLI () (166 aa) fasta scores: E(): 0, 88.6% id in 166 aa. Contains a possible N-terminal signal sequence; Fasta hit to SPY_ECOLI (161 aa), 32% identity in 159 aa overlap.
  
     0.769
STY1317
Putative membrane protein; Similar to Escherichia coli YciC protein TR:BAA14787 (EMBL:D90763) (247 aa) fasta scores: E(): 0, 86.6% id in 247 aa, and to Buchnera aphidicola hypothetical protein BU276 homolog SW:Y276_BUCAP (P42396) (247 aa) fasta scores: E(): 7.5e-21, 29.5% id in 244 aa.
  
     0.768
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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