STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1677Similar to Salmonella typhimurium outer membrane lipoprotein slyb precursor SLYB SW:SLYB_SALTY (Q53549) fasta scores: E(): 0, 100.0% id in 155 aa, and to Escherichia coli outer membrane lipoprotein slyb precursor SLYB SW:SLYB_ECOLI (P55741; P76183) fasta scores: E(): 0, 94.8% id in 155 aa, and to Serratia spATCC39006. outer membrane lipoprotein pcp PCP TR:Q9RA95 (EMBL:AF168597) fasta scores: E(): 0, 71.0% id in 155 aa; Orthologue of E. coli SLYB_ECOLI; Fasta hit to SLYB_ECOLI (155 aa), 95% identity in 155 aa overlap. (155 aa)    
Predicted Functional Partners:
STY1091
Outer membrane protein A; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
  
  
 0.666
STY2542
Conserved hypothetical protein; Fasta hit to YGAM_ECOLI (113 aa), 34% identity in 96 aa overlap; Fasta hit to YQJD_ECOLI (101 aa), 42% identity in 101 aa overlap; Orthologue of E. coli ELAB_ECOLI; Fasta hit to ELAB_ECOLI (101 aa), 89% identity in 101 aa overlap.
  
    0.611
STY3409
Conserved hypothetical protein; Fasta hit to YGAM_ECOLI (113 aa), 41% identity in 99 aa overlap; Fasta hit to ELAB_ECOLI (101 aa), 44% identity in 101 aa overlap; Fasta hit to HNS_ECOLI (136 aa), 31% identity in 110 aa overlap; Orthologue of E. coli yqjD (YQJD_ECOLI); Fasta hit to YQJD_ECOLI (101 aa), 90% identity in 101 aa overlap.
  
    0.605
STY1271
Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells.
   
  
 0.533
STY1270
Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...]
  
  
 0.523
yaeT
Outer membrane protein precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
    
 
 0.510
STY2781
SseB protein; Orthologue of E. coli sseB (SSEB_ECOLI); Fasta hit to SSEB_ECOLI (261 aa), 89% identity in 261 aa overlap.
  
   
 0.507
yejK
Nucleoid-asociated protein; Similar to Escherichia coli 37 kDa nucleoid-associated protein yejK SW:NA37_ECOLI (P33920) (334 aa) fasta scores: E(): 0, 96.4% id in 333 aa and Haemophilus influenzae 37 kDa nucleoid-associated protein homolog HI0839 SW:NA37_HAEIN (P44896) (341 aa) fasta scores: E(): 0, 53.2% id in 333 aa.
      
 0.499
virK
Virulence protein; Identical to Salmonella typhi AJB70 VirK protein TR:O68287 (EMBL:AF029845) (297 aa) fasta scores: E(): 0, 100.0% id in 297 aa. Similar to Salmonella typhimurium SL1344 protein VirK TR:AAB80743 (EMBL:AF020810) (294 aa) fasta scores: E(): 0, 99.3% id in 294 aa; Paralogue of E. coli YBJX_ECOLI; Fasta hit to YBJX_ECOLI (330 aa), 37% identity in 318 aa overlap.
  
  
 0.480
slyA
Transcriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family.
  
  
 0.457
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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