STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydhZConserved hypothetical protein; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate; Belongs to the FumD family. (70 aa)    
Predicted Functional Partners:
STY1494
NAD-linked malic enzyme; Orthologue of E. coli sfcA (MAO1_ECOLI); Fasta hit to MAO1_ECOLI (574 aa), 92% identity in 572 aa overlap; Belongs to the malic enzymes family.
     
 0.909
fumA
Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
     
 0.906
maeB
NADP-dependent malate dehydrogenase (decarboxylating); Similar to Escherichia coli NADP-dependent malic enzyme maeB SW:MAO2_ECOLI (P76558) (759 aa) fasta scores: E(): 0, 94.3% id in 759 aa; Orthologue of E. coli MAO2_ECOLI; Fasta hit to MAO2_ECOLI (759 aa), 94% identity in 759 aa overlap.
     
 0.906
fumB
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
     
 0.906
STY0775
Succinate dehydrogenase cytochrome b-556 subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
     
  0.900
STY0776
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
     
  0.900
STY0777
Succinate dehydrogenase flavoprotein subunit; Fasta hit to NADB_ECOLI (540 aa), 32% identity in 570 aa overlap; Fasta hit to FRDA_ECOLI (601 aa), 43% identity in 597 aa overlap; Orthologue of E. coli sdhA (DHSA_ECOLI); Fasta hit to DHSA_ECOLI (588 aa), 98% identity in 588 aa overlap; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
     
  0.900
STY0778
Succinate dehydrogenase iron-sulfur protein; Fasta hit to FRDB_ECOLI (243 aa), 37% identity in 235 aa overlap; Orthologue of E. coli sdhB (DHSB_ECOLI); Fasta hit to DHSB_ECOLI (238 aa), 96% identity in 238 aa overlap; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
     
  0.900
STY1653
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
     
  0.900
STY3539
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
     
  0.900
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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