STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1768Vitamin B12 ABC transport ATP-binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)    
Predicted Functional Partners:
STY1770
Vitamin B12 transport system permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
 
 
 0.999
btuF
Cobalamin periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
  
 
 0.985
btuE
Putative glutathione peroxidase/vitamin B12 transport periplasmic protein BtuE; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.
  
  
 0.956
STY3744
Vitamin B12 receptor protein; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
  
   
 0.837
ggt
Similar to Escherichia coli gamma-glutamyltranspeptidase precursor ggt SW:GGT_ECOLI (P18956) (580 aa) fasta scores: E(): 0, 91.4% id in 580 aa, and to Helicobacter pylori J99 gamma-glutamyltranspeptidase ggt TR:Q9ZK95 (EMBL:AE001532) (567 aa) fasta scores: E(): 0, 52.7% id in 537 aa. Contains N-terminal signal sequence, probable secreted protein.
      
 0.836
ybiR
Putative membrane protein; Similar to Escherichia coli hypothetical 41.2 kDa protein im ompx-moeb intergenic region ybiR SW:YBIR_ECOLI (P75788) (372 aa) fasta scores: E(): 0, 83.5% id in 370 aa, and to Mycobacterium leprae 46 kDa membrane protein ag45 SW:AG45_MYCLE (P46838) (429 aa) fasta scores: E(): 8.7e-08, 24.4% id in 352 aa, and to Homo sapiens p protein P SW:P_HUMAN (Q04671; Q15212) (838 aa) fasta scores: E(): 2.7e-07, 25.5% id in 341 aa; Orthologue of E. coli YBIR_ECOLI; Fasta hit to YBIR_ECOLI (372 aa), 84% identity in 370 aa overlap.
  
   
 0.828
STY0227
Putative membrane protein; Similar to Deinococcus radiodurans conserved hypothetical protein dr2368 TR:Q9RRW7 (EMBL:AE002067) (215 aa) fasta scores: E(): 5.4e-20, 40.0% id in 205 aa, and to Streptomyces coelicolor putative integral membrane protein sc2a11.15 TR:O86576 (EMBL:AL031184) (219 aa) fasta scores: E(): 3.3e-17, 36.7% id in 196 aa; Fasta hit to YICG_ECOLI (205 aa), 36% identity in 206 aa overlap; Orthologue of E. coli yadS (YADS_ECOLI); Fasta hit to YADS_ECOLI (207 aa), 96% identity in 207 aa overlap.
      
 0.805
STY3232
Possible ABC-transport protein, ATP-binding component; Similar to Pyrococcus abyssi ABC transporter, ATP-binding protein TR:Q9V1Q4 (EMBL:AJ248284) (280 aa) fasta scores: E(): 1.3e-15, 33.6% id in 223 aa. Note the unusual overlap with the upstream CDS.
 
     0.675
STY1441
Putative esterase; Similar to Bacillus sp carboxylesterase estA TR:Q9X6Z3 (EMBL:AJ238680) (485 aa) fasta scores: E(): 0, 37.6% id in 489 aa, and to Bacillus subtilis para-nitrobenzyl esterase pnbA SW:PNBA_BACSU (P37967) (489 aa) fasta scores: E(): 0, 34.9% id in 470 aa; Belongs to the type-B carboxylesterase/lipase family.
      
 0.578
nlpC
Putative lipoprotein; Similar to Escherichia coli probable lipoprotein NlpC precursor nlpC SW:NLPC_ECOLI (P23898) (154 aa) fasta scores: E(): 0, 85.7% id in 154 aa, and to Haemophilus influenzae hypothetical lipoprotein Hi1314 precursor hi1314 SW:YD14_HAEIN (Q57223; O05058) (161 aa) fasta scores: E(): 1.1e-27, 48.4% id in 155 aa.
       0.567
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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