STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
STY1770Vitamin B12 transport system permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. (326 aa)    
Predicted Functional Partners:
STY1768
Vitamin B12 ABC transport ATP-binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
 
 
 0.999
btuF
Cobalamin periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
 
 
 0.998
STY3744
Vitamin B12 receptor protein; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
 
   
 0.871
STY3313
Possible ABC-transport protein, periplasmic-binding component; Similar to several including: Haemophilus influenzae hypothetical protein HI1472 SW:YE72_HAEIN (P44206) (351 aa) fasta scores: E(): 0, 57.7% id in 343 aa and Archaeoglobus fulgidus iron (III) ABC transporter, ATP-binding protein AF0432 TR:O29817 (EMBL:AE001075) (366 aa) fasta scores: E(): 2e-12, 29.0% id in 362 aa. Contains a possible N-terminal signal sequence.
 
 
 
 0.851
STY0227
Putative membrane protein; Similar to Deinococcus radiodurans conserved hypothetical protein dr2368 TR:Q9RRW7 (EMBL:AE002067) (215 aa) fasta scores: E(): 5.4e-20, 40.0% id in 205 aa, and to Streptomyces coelicolor putative integral membrane protein sc2a11.15 TR:O86576 (EMBL:AL031184) (219 aa) fasta scores: E(): 3.3e-17, 36.7% id in 196 aa; Fasta hit to YICG_ECOLI (205 aa), 36% identity in 206 aa overlap; Orthologue of E. coli yadS (YADS_ECOLI); Fasta hit to YADS_ECOLI (207 aa), 96% identity in 207 aa overlap.
      
 0.799
STY0219
Ferrichrome transport ATP-binding protein FhuC; Fasta hit to FEPC_ECOLI (271 aa), 44% identity in 237 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 44% identity in 239 aa overlap; Fasta hit to LIVF_ECOLI (237 aa), 30% identity in 225 aa overlap; Fasta hit to PHNK_ECOLI (252 aa), 30% identity in 217 aa overlap; Fasta hit to HISP_ECOLI (257 aa), 32% identity in 224 aa overlap; Fasta hit to BTUD_ECOLI (249 aa), 35% identity in 232 aa overlap; Fasta hit to PHNL_ECOLI (226 aa), 33% identity in 216 aa overlap; Fasta hit to PHNC_ECOLI (262 aa), 32% identity in 232 aa overlap; Fasta hit to NIK [...]
 
   
 0.781
STY0634
Ferric enterobactin transport ATP-binding protein FepC; Fasta hit to SSUB_ECOLI (255 aa), 33% identity in 225 aa overlap; Fasta hit to FHUC_ECOLI (265 aa), 45% identity in 237 aa overlap; Fasta hit to FECE_ECOLI (255 aa), 49% identity in 250 aa overlap; Fasta hit to HISP_ECOLI (257 aa), 31% identity in 229 aa overlap; Fasta hit to PHNC_ECOLI (262 aa), 30% identity in 246 aa overlap; Fasta hit to YECC_ECOLI (250 aa), 31% identity in 225 aa overlap; Fasta hit to YRBF_ECOLI (269 aa), 30% identity in 267 aa overlap; Fasta hit to GLNQ_ECOLI (240 aa), 33% identity in 220 aa overlap; Fasta hi [...]
 
     0.778
btuE
Putative glutathione peroxidase/vitamin B12 transport periplasmic protein BtuE; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.
    
 0.754
STY1765
Conserved hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
    
 0.749
STY0220
Ferrichrome-binding periplasmic protein precursor; Orthologue of E. coli fhuD (FHUD_ECOLI); Fasta hit to FHUD_ECOLI (296 aa), 84% identity in 292 aa overlap.
 
 
 
 0.695
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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