STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfcO-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS. (407 aa)    
Predicted Functional Partners:
STY2174
Conserved hypothetical protein; Fasta hit to YHHP_ECOLI (81 aa), 31% identity in 72 aa overlap; Orthologue of E. coli yedF (YEDF_ECOLI); Fasta hit to YEDF_ECOLI (77 aa), 100% identity in 77 aa overlap; Belongs to the sulfur carrier protein TusA family.
      
 0.613
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
      
 0.502
sinR
Similar to Salmonella typhimurium regulatory protein SinR SW:SINR_SALTY (P37459) (315 aa) fasta scores: E(): 0, 99.7% id in 314 aa and to Escherichia coli hypothetical transcriptional regulator in dmsc-pfla intergenic region ycaN SW:YCAN_ECOLI (P75836) (302 aa) fasta scores: E(): 3.7e-18, 29.1% id in 309 aa, and to Vibrio cholerae AphB (involved in activation expression of the ToxR virulence cascade) aphB TR:Q9XC54 (EMBL:AF148502) (291 aa) fasta scores: E(): 2e-15, 24.9% id in 293 aa.
      
 0.414
STY0154
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
      
 0.410
STY1162
PhoH protein (phosphate starvation-inducible protein PsiH); Orthologue of E. coli phoH (PHOH_ECOLI); Fasta hit to PHOH_ECOLI (354 aa), 93% identity in 284 aa overlap.
      
 0.410
STY1778
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
      
 0.410
STY3629
Putative lipopolysaccharide biosynthesis protein; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
      
 0.410
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.