STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
astAArginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (344 aa)    
Predicted Functional Partners:
astB
Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).
 
 
 0.999
astD
Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
 
  
 0.995
astC
Succinylornithine transaminase; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
 
  
 0.984
astE
Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
 
  
 0.967
speA
Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine.
  
  
  0.912
adi
Arginine decarboxylase; Similar to Escherichia coli biodegradative arginine decarboxylase SW:ADI_ECOLI (P28629) (755 aa) fasta scores: E(): 0, 93.1% id in 755 aa, and to Escherichia coli lysine decarboxylase, constitutive SW:DCLZ_ECOLI (P52095) (713 aa) fasta scores: E(): 0, 36.2% id in 737 aa.
   
 
  0.905
STY4805
Arginine deiminase; Similar to Pseudomonas aeruginosa arginine deiminase SW:ARCA_PSEAE (P13981) (417 aa) fasta scores: E(): 0, 46.8% id in 408 aa, and to Rhizobium etli arginine deiminase TR:O31017 (EMBL:AF025543) (409 aa) fasta scores: E(): 0, 47.3% id in 402 aa.
     
 0.856
STY3750
Argininosuccinate lyase; Orthologue of E. coli argH (ARLY_ECOLI); Fasta hit to ARLY_ECOLI (457 aa), 95% identity in 456 aa overlap.
     
 0.809
argD
Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways.
 
  
 0.674
STY3396
Probable aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
  
  
 0.496
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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