STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
msgAPutative virulence protein; Affects survival in macrophages. (79 aa)    
Predicted Functional Partners:
envE
Putative lipoprotein; Similar to Salmonella typhimurium probable lipoprotein enve precursor. probable lipoprotein enve precursor SW:ENVE_SALTY (Q56030) (178 aa) fasta scores: E(): 0, 92.8% id in 111 aa.
     
 0.669
pagC
Similar to Salmonella typhimurium virulence membrane protein pagc precursor. virulence membrane protein pagc precursor SW:PAGC_SALTY (P23988) (188 aa) fasta scores: E(): 0, 95.2% id in 188 aa, and to Salmonella typhimurium RcK protein precursor rcK TR:Q04817 (EMBL:L08613) (185 aa) fasta scores: E(): 0, 51.6% id in 186 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 3.7e-14, 36.6% id in 191 aa.
      
 0.585
sitC
Iron transport protein, inner membrane component; Similar to Salmonella typhimurium SitC an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCS0 (EMBL:AF128999) (286 aa) fasta scores: E(): 0, 99.7% id in 286 aa and to Yersinia pestis chelated iron transport system membrane protein YfeC SW:YFEC_YERPE (Q56954) (294 aa) fasta scores: E(): 0, 66.5% id in 281 aa. Contains multiple possible membrane spanning hydrophobic domains.
      
 0.575
sipB
Pathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...]
      
 0.527
pagD
Putative outer membrane virulence protein; Similar to Salmonella typhimurium virulence protein pagd precursor. virulence protein pagd precursor SW:PAGD_SALTY (Q56029) (87 aa) fasta scores: E(): 0, 95.4% id in 87 aa.
      
 0.508
cspH
Similar to Salmonella typhimurium cold shock-like protein cspH. cold shock-like protein CspH SW:CSPH_SALTY (O33793) (70 aa) fasta scores: E(): 2.6e-31, 98.6% id in 70 aa, and to Escherichia coli cold shock-like protein csph csph or cspK SW:CSPH_ECOLI (P56253) (70 aa) fasta scores: E(): 7.1e-24, 80.0% id in 70 aa, and to Yersinia enterocolitica major cold shock protein Cspa1 cspa1 TR:Q9RIF2 (EMBL:U82821) (70 aa) fasta scores: E(): 3.5e-11, 52.2% id in 67 aa.
      
 0.501
prgH
Pathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains.
      
 0.499
sifA
Putative virulence determinant; Similar to Salmonella typhimurium SifA protein sifA SW:SIFA_SALTY (Q56061) (336 aa) fasta scores: E(): 0, 93.5% id in 336 aa.
      
 0.496
invA
Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
      
 0.496
tolC
Similar to Salmonella enteritidis outer membrane protein TolC precursor tolC SW:TOLC_SALEN (Q54001) (491 aa) fasta scores: E(): 0, 99.0% id in 491 aa, and to Escherichia coli outer membrane protein tolc precursor tolc or mtcb or muka or refI SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 89.7% id in 495 aa; Orthologue of E. coli tolC (TOLC_ECOLI); Fasta hit to TOLC_ECOLI (495 aa), 90% identity in 495 aa overlap.
      
 0.439
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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