STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mltEMembrane-bound lytic murein transglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa)    
Predicted Functional Partners:
STY3128
Membrane-bound lytic murein transglycosylase A precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
      
 0.823
STY2952
Membrane-bound lytic transglycosylase B precursor; Orthologue of E. coli mltB (MLTB_ECOLI); Fasta hit to MLTB_ECOLI (361 aa), 92% identity in 361 aa overlap.
      
 0.609
STY1928
Similar to Escherichia coli hypothetical 33.6 kDa protein in dadX-mltE intergenic region ycgQ SW:YCGQ_ECOLI (P76008) (304 aa) fasta scores: E(): 0, 79.6% id in 304 aa, and to Neisseria meningitidis hypothetical protein NMA1819 or mccF TR:CAB85044 (394 aa) fasta scores: E(): 0, 39.5% id in 306 aa, and to Streptomyces coelicolor hypothetical 32.8 kDa protein SC9C7.25. hypothetical protein SC9C7.25 SW:YC25_STRCO (Q9ZBI5) (310 aa) fasta scores: E(): 3.7e-20, 32.9% id in 307 aa.
       0.512
STY1249
Putative glycosyl hydrolase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
      
 0.415
STY0104
CorD protein; Similar to Salmonella typhimurium ApaG protein SW:APAG_SALTY (Q56017) fasta scores: E(): 0, 97.6% id in 125 aa, and to Escherichia coli ApaG protein APAG SW:APAG_ECOLI (P05636) fasta scores: E(): 0, 92.8% id in 125 aa, and to C-terminus of Homo sapiens f-box protein fbx3 TR:Q9UK99 (EMBL:AF176702) fasta scores: E(): 2.1e-09, 35.8% id in 123 aa.
      
 0.414
STY4182
Putative polysaccharide biosynthesis protein subunit B; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family.
      
 0.412
STY0103
Bis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.
      
 0.411
STY3859
Putative glycosyl hydrolase; Similar to Escherichia coli hypothetical protein YihQ SW:YIHQ_ECOLI (P32138; P76775) (678 aa) fasta scores: E(): 0, 88.4% id in 674 aa. Also weakly similar to Sulfolobus solfataricus alpha-glucosidase SW:AGLU_SULSO () (693 aa) fasta scores: E(): 3e-15, 22.2% id in 603 aa; Orthologue of E. coli yihQ (YIHQ_ECOLI); Fasta hit to YIHQ_ECOLI (678 aa), 88% identity in 674 aa overlap; Belongs to the glycosyl hydrolase 31 family.
      
 0.410
STY3860
Putative membrane permease; Similar to Escherichia coli hypothetical symporter SW:YIHP_ECOLI () (461 aa) fasta scores: E(): 0, 90.9% id in 460 aa and to Escherichia coli glucuronide carrier protein UidB SW:UIDB_ECOLI (P30868; P77457) (457 aa) fasta scores: E(): 0, 34.1% id in 455 aa. Note this CDS is highly similar to the downstream CDS STY3861; Fasta hit to UIDB_ECOLI (457 aa), 34% identity in 455 aa overlap; Fasta hit to YIHO_ECOLI (487 aa), 65% identity in 458 aa overlap.
      
 0.410
ipk
Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily.
     
 0.401
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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