STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1948long-chain-fatty-acid--CoA ligase; Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids; Belongs to the ATP-dependent AMP-binding enzyme family. (561 aa)    
Predicted Functional Partners:
STY0354
Possible acyl-CoA dehydrogenase; Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for the utilization of medium- and long- chain fatty acids as sole carbon sources for growth. Is needed for bacterial survival during carbone-source starvation.
 
 
 0.914
STY2623
Long-chain fatty acid transport protein precursor; Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity). Belongs to the OmpP1/FadL family.
 
  
 0.860
STY3577
Large (alpha) subunit of the fatty acid-oxidizing multienzyme complex; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
 
 
 0.847
STY2620
Putative fatty acid oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
 
 
 0.820
STY3578
Small (beta) subunit of the fatty acid-oxidizing multienzyme complex; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity).
  
 
 0.693
STY0631
Enterobactin synthetase component F; Orthologue of E. coli entF (ENTF_ECOLI); Fasta hit to ENTF_ECOLI (1293 aa), 79% identity in 1294 aa overlap.
  
 
0.685
aidB
Probable acyl Co-A dehydrogenase; Similar to Escherichia coli AidB protein SW:AIDB_ECOLI (P33224) (546 aa) fasta scores: E(): 0, 85.2% id in 539 aa and to Streptomyces coelicolor putative oxidoreductase 2scg38.05 TR:CAC13064 (EMBL:AL445503) (567 aa) fasta scores: E(): 0, 44.2% id in 545 aa.
 
 
 0.659
rplF
50S ribosomal subunit protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
 0.618
STY1947
Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.
       0.604
STY2435
Lysine-specific permease; Fasta hit to CYCA_ECOLI (470 aa), 35% identity in 463 aa overlap; Fasta hit to PHEP_ECOLI (458 aa), 37% identity in 469 aa overlap; Fasta hit to YIFK_ECOLI (461 aa), 37% identity in 477 aa overlap; Fasta hit to PROY_ECOLI (457 aa), 37% identity in 449 aa overlap; Fasta hit to GABP_ECOLI (466 aa), 33% identity in 436 aa overlap; Fasta hit to MMUP_ECOLI (475 aa), 40% identity in 450 aa overlap; Fasta hit to ANSP_ECOLI (499 aa), 33% identity in 459 aa overlap; Fasta hit to AROP_ECOLI (457 aa), 35% identity in 457 aa overlap; Orthologue of E. coli lysP (LYSP_ECOLI [...]
      
 0.562
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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