STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1975Heat shock protein; Orthologue of E. coli htpX (HTPX_ECOLI); Fasta hit to HTPX_ECOLI (293 aa), 96% identity in 293 aa overlap; Belongs to the peptidase M48B family. (293 aa)    
Predicted Functional Partners:
STY3474
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
   
 
 0.732
STY1112
Putative membrane protein; Orthologue of E. coli yccA (YCCA_ECOLI); Fasta hit to YCCA_ECOLI (219 aa), 95% identity in 219 aa overlap; Belongs to the BI1 family.
  
  
 0.655
kefB
Glutathione-regulated potassium-efflux system protein (K(+)/H(+)antiporter); Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
  
  
 0.653
STY2868
Heat shock protein GrpE (heat shock protein b25.3) (hsp24); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the rea [...]
  
  
 0.544
STY3811
Extracytoplasmic stress protein for protein-mediated toxicities; Similar to Escherichia coli periplasmic protein CpxP precursor SW:CPXP_ECOLI () (166 aa) fasta scores: E(): 0, 88.6% id in 166 aa. Contains a possible N-terminal signal sequence; Fasta hit to SPY_ECOLI (161 aa), 32% identity in 159 aa overlap.
   
  
 0.532
STY0231
Protease DO precursor; Fasta hit to DEGQ_ECOLI (455 aa), 57% identity in 478 aa overlap; Orthologue of E. coli htrA (HTRA_ECOLI); Fasta hit to HTRA_ECOLI (474 aa), 92% identity in 475 aa overlap; Belongs to the peptidase S1C family.
  
  
 0.492
STY1976
Tail-specific protease precursor; Orthologue of E. coli prc (PRC_ECOLI); Fasta hit to PRC_ECOLI (682 aa), 93% identity in 682 aa overlap; Belongs to the peptidase S41A family.
     
 0.479
ybbN
Thioredoxin-like protein; Similar to Escherichia coli hypothetical 33.1 kDa protein in usha-tesa intergenic region ybbN SW:YBBN_ECOLI (P77395) (296 aa) fasta scores: E(): 0, 93.8% id in 290 aa, and to Alicyclobacillus acidocaldarius thioredoxin trxA SW:THIO_ALIAC (P80579) (105 aa) fasta scores: E(): 1.5e-07, 35.6% id in 104 aa, and to Escherichia coli thioredoxin 2 trxC SW:THI2_ECOLI (P33636; P76593; P77000; P77001) (139 aa) fasta scores: E(): 1e-06, 29.5% id in 105 aa. Note that the redox-active disulphide pair is not conserved; Orthologue of E. coli YBBN_ECOLI; Fasta hit to YBBN_ECOL [...]
  
  
 0.474
STY1312
Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
 
   
 0.474
STY0013
DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...]
  
 
 0.468
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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