STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2136Conserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (131 aa)    
Predicted Functional Partners:
ybdQ
Conserved hypothetical protein; Similar to Escherichia coli unknown protein from 2d-page ybdQ SW:UP12_ECOLI (P39177; P77720) (142 aa) fasta scores: E(): 0, 89.4% id in 142 aa, and to Escherichia coli unknown protein 2d_000b3l from 2d-page ynaF SW:UP03_ECOLI (P37903; P76074; P76853) (144 aa) fasta scores: E(): 9.6e-16, 37.7% id in 146 aa; Fasta hit to UP03_ECOLI (144 aa), 38% identity in 146 aa overlap; Orthologue of E. coli UP12_ECOLI; Fasta hit to UP12_ECOLI (142 aa), 89% identity in 142 aa overlap; Belongs to the universal stress protein A family.
  
  
 0.914
STY1403
Conserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
   
  
 0.879
STY1416
Conserved hypothetical protein; Fasta hit to UP12_ECOLI (142 aa), 40% identity in 146 aa overlap; Orthologue of E. coli UP03_ECOLI; Fasta hit to UP03_ECOLI (144 aa), 91% identity in 144 aa overlap.
  
  
 0.876
smp
Putative membrane protein; Similar to Escherichia coli smp protein precursor SW:SMP_ECOLI (P18838) (214 aa) fasta scores: E(): 0, 91.1% id in 214 aa.
  
   
 0.814
STY2135
Hypothetical protein; Unknown function.
       0.783
holD
DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
  
     0.761
STY3782
Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
  
    0.749
STY3527
Conserved hypothetical protein; Orthologue of E. coli yhcB (YHCB_ECOLI); Fasta hit to YHCB_ECOLI (134 aa), 96% identity in 132 aa overlap.
  
     0.744
STY0994
Killing factor KicB; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
  
     0.717
STY3777
Cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
  
    0.709
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.