STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fliZFliZ protein; May regulate sigma factor activity. (183 aa)    
Predicted Functional Partners:
fliA
RNA polymerase sigma transcription factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily.
  
  
 0.997
STY1222
Flagellar hook-associated protein 1; Orthologue of E. coli flgK (FLGK_ECOLI); Fasta hit to FLGK_ECOLI (546 aa), 80% identity in 554 aa overlap.
   
 
 0.956
STY2996
AraC-family transcriptional regulator; Similar to several from Salmonella typhimurium including: TR:Q9X5C3 (EMBL:AF124398) HilD transcriptional regulator (309 aa) fasta scores: E(): 0, 99.4% id in 309 aa and SW:YGBG_SALTY (P41782) hypothetical 17.2 kDa protein found upstream of prgH fasta scores: E(): 0, 87.9% id in 132 aa.
      
 0.877
STY1211
Negative regulator of flagellin synthesis (anti-sigma factor); Orthologue of E. coli flgM (FLGM_ECOLI); Fasta hit to FLGM_ECOLI (97 aa), 80% identity in 96 aa overlap.
   
  
 0.854
STY2134
Flagellar transcriptional activator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.
   
  
 0.779
sprA
Possible AraC-family transcriptional regulator; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1).
      
 0.768
STY1213
Putative flagellar basal-body rod protein FlgB (proximal rod protein); Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
  
 0.746
fliD
Flagellar hook associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
   
  
 0.670
STY1210
Flagella synthesis protein FlgN; Required for the efficient initiation of filament assembly. Belongs to the FlgN family.
   
  
 0.669
STY1215
Flagellar hook formation protein FlgD; Required for flagellar hook formation. May act as a scaffolding protein (By similarity).
   
    0.667
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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