STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fliARNA polymerase sigma transcription factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)    
Predicted Functional Partners:
STY1211
Negative regulator of flagellin synthesis (anti-sigma factor); Orthologue of E. coli flgM (FLGM_ECOLI); Fasta hit to FLGM_ECOLI (97 aa), 80% identity in 96 aa overlap.
 
 0.999
fliZ
FliZ protein; May regulate sigma factor activity.
  
  
 0.997
STY1222
Flagellar hook-associated protein 1; Orthologue of E. coli flgK (FLGK_ECOLI); Fasta hit to FLGK_ECOLI (546 aa), 80% identity in 554 aa overlap.
 
  
 0.991
STY1213
Putative flagellar basal-body rod protein FlgB (proximal rod protein); Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
 
 
 0.986
STY2131
Motility protein B; Similar to e.g. Salmonella typhimurium chemotaxis motB protein SW:MOTB_SALTY (P55892) (309 aa) fasta scores: E(): 0, 99.7% id in 309 aa. Contains hydrophobic, probable membrane-spanning region; Orthologue of E. coli MotB (MOTB_ECOLI); Fasta hit to MOTB_ECOLI (308 aa), 90% identity in 309 aa overlap.
 
  
 0.973
STY1216
Flagellar hook protein FlgE; Orthologue of E. coli flgE (FLGE_ECOLI); Fasta hit to FLGE_ECOLI (401 aa), 88% identity in 403 aa overlap.
 
  
 0.969
STY1214
Putative flagellar basal-body rod protein FlgC (proximal rod protein); Orthologue of E. coli flgC (FLGC_ECOLI); Fasta hit to FLGC_ECOLI (134 aa), 93% identity in 134 aa overlap; Belongs to the flagella basal body rod proteins family.
 
 
 0.967
fliC
Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
 
  
 0.961
fliD
Flagellar hook associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
 
  
 0.959
STY2184
Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
 
 
 0.959
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.