STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2404Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (312 aa)    
Predicted Functional Partners:
STY3565
Fis DNA-binding protein; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family.
  
  
 0.603
STY2723
Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
   
  
 0.584
STY2406
glutathione-S-transferase-family protein; Similar to e.g. Pseudomonas sp. U2 glutathione-S-transferase homolog from plasmid pWWU2 nagL TR:O86043 (EMBL:AF081362) (212 aa) fasta scores: E(): 2.4e-28, 42.1% id in 214 aa and Homo sapiens maleylacetoacetate isomerase gstz1 or maaI SW:MAAI_HUMAN (O43708; O15308; O75430) (216 aa) fasta scores: E(): 1.7e-24, 40.8% id in 211 aa. May be maleylpyruvate isomerase, given the presence of a putative gentisate 1,2-dioxygenase upstream.
   
   0.549
STY2405
Putative n-hydroxybenzoate hydroxylase; Similar to hydroxylases/monooxygenases e.g. Pseudomonas stutzeri salicylate hydroxylase nahW TR:Q9ZI64 (EMBL:AF039534) (389 aa) fasta scores: E(): 9.9e-29, 28.9% id in 387 aa overlap. Similar to Bordetella pertussis hypothetical protein TR:O30447 (EMBL:AF006000) (406 aa) fasta scores: E(): 0, 33.2% id in 398 aa. May produce gentisate, given presence of putative gentisate 1,2-dioxygenase upstream.
       0.545
STY2407
FAA-hydrolase-family protein; Similar to Pseudomonas sp. U2 putative isomerase-decarboxylase homolog from plasmid pWWU2 nagK TR:O86042 (EMBL:AF081362) (192 aa) fasta scores: E(): 2.7e-30, 46.9% id in 196 aa. May be fumarylpyruvate hydrolase, given the presence of putative gentisate 1,2-dioxygenase and putative maleylpyruvate isomerase in this gene cassette; Paralogue of E. coli P76004; Fasta hit to P76004 (219 aa), 39% identity in 208 aa overlap.
  
    0.541
STY2408
Putative gentisate 1,2-dioxygenase; Similar to several e.g. Pseudomonas alcaligenes gentisate 1,2-dioxygenase xlnE TR:Q9S3U6 (EMBL:AF173167) (347 aa) fasta scores: E(): 0, 53.3% id in 338 aa.
       0.505
STY2409
Putative n-hydroxybenzoate transporter; Similar to e.g. Pseudomonas putida 4-hydroxybenzoate transporter pcaK SW:PCAK_PSEPU (Q51955) (448 aa) fasta scores: E(): 0, 43.8% id in 422 aa and Acinetobacter calcoaceticus 4-hydroxybenzoate transporter pcaK SW:PCAK_ACICA (Q43975) (457 aa) fasta scores: E(): 0, 43.2% id in 438 aa.
       0.481
STY2402
Putative lipoprotein; Shows weak similarity to e.g. Pseudomonas aeruginosa outer membrane protein OprM precursor oprM or oprK SW:OPRM_PSEAE (Q51487; Q51444) (477 aa) fasta scores: E(): 7.1e-20, 25.5% id in 491 aa. Contains probable N-terminal signal sequence; Fasta hit to YJCP_ECOLI (488 aa), 37% identity in 488 aa overlap; Orthologue of E. coli yohG (YOHG_ECOLI); Fasta hit to YOHG_ECOLI (398 aa), 85% identity in 396 aa overlap.
      
 0.463
rluA
Ribosomal large subunit pseudouridine synthase A; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
  
   
 0.454
STY0199
Pantoate:beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
    0.446
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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