STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfbBConserved hypothetical protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (252 aa)    
Predicted Functional Partners:
menD
Menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.999
menC
O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
 
 0.994
menE
O-succinylbenzoic acid-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
 
 
 0.954
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
   
 0.949
STY1757
Similar to Haemophilus influenzae hypothetical protein Hi1161 hi1161 SW:YBDB_HAEIN (P45083) (138 aa) fasta scores: E(): 8.4e-24, 51.2% id in 129 aa; Fasta hit to YBDB_ECOLI (137 aa), 58% identity in 130 aa overlap; Orthologue of E. coli P77781; Fasta hit to P77781 (136 aa), 90% identity in 130 aa overlap.
 
   
 0.902
menF
Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
 
   
 0.886
STY4211
Putative PTR2 family transport protein; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily.
      
 0.814
STY0266
Copper homeostasis protein CutF precursor (lipoprotein nlpE); Orthologue of E. coli CutF (CUTF_ECOLI); Fasta hit to CUTF_ECOLI (236 aa), 76% identity in 232 aa overlap. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
      
 0.811
STY2945
Putative membrane protein; Similar to e.g. Haemophilus influenzae hypothetical protein HI0489 SW:YQAA_HAEIN (P44005) (157 aa) fasta scores: E(): 4.5e-18, 46.6% id in 133 aa, Neisseria meningitidis hypothetical protein NMB0534 TR:AAF40963 (EMBL:UNNKOWN ACCESSION) (137 aa) fasta scores: E(): 4.8e-12, 36.9% id in 130 aa and Neisseria meningitidis putative membrane protein NMA0712 TR:CAB83998 (EMBL:UNNKOWN ACCESSION) (137 aa) fasta scores: E(): 6.6e-12, 36.9% id in 130 aa. Contains hydrophobic, probable membrane-spanning regions; Orthologue of E. coli YQAA_ECOLI; Fasta hit to YQAA_ECOLI (1 [...]
      
 0.805
ybaO
Similar to Escherichia coli hypothetical transcriptional regulator in mdl-cof intergenic region ybaO SW:YBAO_ECOLI (P54986; P71209; P77575) (152 aa) fasta scores: E(): 0, 95.4% id in 152 aa, and to Zymomonas mobilis glutamate uptake regulatory protein grP SW:GRP_ZYMMO (P74996) (164 aa) fasta scores: E(): 9.7e-26, 44.0% id in 150 aa, and to Pseudomonas putida bkd operon transcriptional regulator bkdR SW:BKDR_PSEPU (P42179) (161 aa) fasta scores: E(): 1.2e-17, 35.3% id in 153 aa; Fasta hit to LRP_ECOLI (163 aa), 34% identity in 151 aa overlap; Orthologue of E. coli YBAO_ECOLI; Fasta hit [...]
   
  
 0.790
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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