STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
STY2586Putative decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN. (189 aa)    
Predicted Functional Partners:
STY3047
Conserved hypothetical protein; Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives.
 
 
 0.987
STY3581
Conserved hypothetical protein; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
 
 
 0.987
STY4430
4-hydroxybenzoate octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
  
 0.945
STY3048
Similar to Streptomyces sp. D7 hypothetical protein VdcD which is encoded by a gene within the vanillic acid decarboxylation cluster TR:Q9X698 (EMBL:AF134589) (79 aa) fasta scores: E(): 3.4e-17, 60.6% id in 71 aa.
    
 0.907
STY3212
Possible monooxygenase; Highly similar to Escherichia coli hypothetical protein VisC SW:VISC_ECOLI (P25535) (400 aa) fasta scores: E(): 0, 86.1% id in 388 aa and also weakly similar to Escherichia coli 2-octaprenyl-6-methoxyphenol hydroxylase VisB SW:UBIH_ECOLI (P25534) (392 aa) fasta scores: E(): 2.7e-29, 29.7% id in 390 aa; Fasta hit to YLEB_ECOLI (391 aa), 38% identity in 380 aa overlap; Orthologue of E. coli visC (VISC_ECOLI); Fasta hit to VISC_ECOLI (400 aa), 86% identity in 388 aa overlap.
     
 0.906
STY3046
Possible decarboxylase; Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.
  
  
 
0.904
STY2585
Similar to Salmonella typhimurium lysine-arginine-ornithine-binding periplasmic protein precursor argT SW:ARGT_SALTY (P02911) (260 aa) fasta scores: E(): 0, 99.2% id in 260 aa; Fasta hit to HISJ_ECOLI (260 aa), 68% identity in 259 aa overlap; Fasta hit to ARTI_ECOLI (243 aa), 34% identity in 255 aa overlap; Fasta hit to ARTJ_ECOLI (243 aa), 36% identity in 254 aa overlap; Fasta hit to GLNH_ECOLI (248 aa), 32% identity in 253 aa overlap; Orthologue of E. coli argT (ARGT_ECOLI); Fasta hit to ARGT_ECOLI (260 aa), 92% identity in 260 aa overlap; Belongs to the bacterial solute-binding prot [...]
     
 0.602
STY2587
Similar to many e.g. Bacillus subtilis amino-acid permease RocE rocE SW:ROCE_BACSU (P39137) (467 aa) fasta scores: E(): 0, 39.5% id in 418 aa. Contains hydrophobic, probable membrane-spanning regions; Fasta hit to CYCA_ECOLI (470 aa), 34% identity in 409 aa overlap; Fasta hit to PHEP_ECOLI (458 aa), 33% identity in 423 aa overlap; Fasta hit to LYSP_ECOLI (488 aa), 38% identity in 429 aa overlap; Fasta hit to YIFK_ECOLI (461 aa), 34% identity in 424 aa overlap; Fasta hit to PROY_ECOLI (457 aa), 35% identity in 405 aa overlap; Fasta hit to GABP_ECOLI (466 aa), 35% identity in 431 aa over [...]
       0.502
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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