STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgtCPhosphoglycerate transport regulatory protein PgtC precursor; Required for pgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. (397 aa)    
Predicted Functional Partners:
pgtB
Similar to Salmonella typhimurium phosphoglycerate transport system sensor protein PgtB pgtB SW:PGTB_SALTY (P37433) (593 aa) fasta scores: E(): 0, 98.6% id in 513 aa, and to Vibrio cholerae putative phosphoglycerate transport regulatory protein pgtB, vca0705 TR:Q9KLN8 (EMBL:AE004400) (789 aa) fasta scores: E(): 1.4e-26, 25.0% id in 781 aa, and to Rhizobium leguminosarum c4-dicarboxylate transport sensor protein DctB dctB SW:DCTB_RHILE (P10047) (622 aa) fasta scores: E(): 2.7e-21, 35.1% id in 259 aa.
 
  
 0.999
pgtA
Similar to Salmonella typhimurium phosphoglycerate transport system transcriptional regulatory protein PgtA pgtA SW:PGTA_SALTY (P06184) (415 aa) fasta scores: E(): 0, 98.1% id in 415 aa.
 
   
 0.932
pgtP
Similar to Salmonella typhimurium phosphoglycerate transporter protein pgtP SW:PGTP_SALTY (P12681) (406 aa) fasta scores: E(): 0, 95.8% id in 406 aa; Fasta hit to UHPT_ECOLI (463 aa), 33% identity in 464 aa overlap; Fasta hit to UHPC_ECOLI (439 aa), 31% identity in 442 aa overlap; Paralogue of E. coli glpT (GLPT_ECOLI); Fasta hit to GLPT_ECOLI (452 aa), 37% identity in 456 aa overlap.
 
  
 0.893
ttrC
Similar to Salmonella typhimurium tetrathionate reductase subunit C TtrC TR:Q9Z4S7 (EMBL:AJ224978) (340 aa) fasta scores: E(): 0, 98.2% id in 340 aa.
  
   
 0.835
STY3781
Menaquinone biosynthesis protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
      
 0.816
STY1167
Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family.
  
     0.723
STY0124
Putative ABC transporter integral membrane protein; Orthologue of E. coli yabK (YABK_ECOLI); Fasta hit to YABK_ECOLI (536 aa), 90% identity in 536 aa overlap.
  
  
 0.684
ttrB
Similar to Salmonella typhimurium tetrathionate reductase subunit B TtrB TR:Q9Z4S8 (EMBL:AJ224978) (250 aa) fasta scores: E(): 0, 100.0% id in 250 aa and to Salmonella typhimurium thiosulfate reductase electron transport protein PhsB SW:PHSB_SALTY (P37601) (192 aa) fasta scores: E(): 1.1e-25, 46.4% id in 151 aa; Fasta hit to P77375 (239 aa), 33% identity in 228 aa overlap; Paralogue of E. coli nrfC (NRFC_ECOLI); Fasta hit to NRFC_ECOLI (223 aa), 41% identity in 222 aa overlap.
      
 0.684
pagC
Similar to Salmonella typhimurium virulence membrane protein pagc precursor. virulence membrane protein pagc precursor SW:PAGC_SALTY (P23988) (188 aa) fasta scores: E(): 0, 95.2% id in 188 aa, and to Salmonella typhimurium RcK protein precursor rcK TR:Q04817 (EMBL:L08613) (185 aa) fasta scores: E(): 0, 51.6% id in 186 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 3.7e-14, 36.6% id in 191 aa.
  
   
 0.631
STY0380
Possible outer membrane protein; Similar to Salmonella typhimurium hypothetical 19.7 kDa protein TR:Q9RFV4 (EMBL:AF166275) (174 aa) fasta scores: E(): 0, 98.9% id in 174 aa, and to Yersinia enterocolitica attachment invasion locus protein precursor aiL SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 4.3e-20, 40.2% id in 169 aa, and to Escherichia coli outer membrane protein x precursor ompX SW:OMPX_ECOLI (P36546) (171 aa) fasta scores: E(): 3.3e-15, 39.5% id in 157 aa, and to Salmonella typhimurium virulence membrane protein pagc precursor. virulence membrane protein pagc precursor S [...]
  
   
 0.614
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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