STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntHManganese transport protein MntH; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. (413 aa)    
Predicted Functional Partners:
STY0876
Transcriptional regulator (iron dependant repressor family); In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family.
 
  
 0.924
STY1963
Putative membrane protein; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
      
 0.810
sitA
Similar to Salmonella typhimurium SitA, an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCS2 (EMBL:AF128999) (305 aa) fasta scores: E(): 0, 100.0% id in 305 aa and to Yersinia pestis YfeA TR:Q56952 (EMBL:U50597) (322 aa) fasta scores: E(): 0, 62.2% id in 275 aa; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.800
STY3368
Putative membrane protein; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions (By similarity); Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
  
  
 0.789
feoB
Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system.
      
 0.767
STY3749
Hydrogen peroxide-inducible regulon activator; Fasta hit to YNFL_ECOLI (297 aa), 32% identity in 248 aa overlap; Fasta hit to CYNR_ECOLI (299 aa), 31% identity in 273 aa overlap; Orthologue of E. coli oxyR (OXYR_ECOLI); Fasta hit to OXYR_ECOLI (305 aa), 96% identity in 305 aa overlap; Belongs to the LysR transcriptional regulatory family.
      
 0.614
STY0544
Copper-transporting ATPase; [Copper-exporting P-type ATPase]: Involved in Cu(+) export (By similarity).
  
 
 0.560
STY3816
Manganese superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
      
 0.507
STY2101
High-affinity zinc uptake system membrane protein; Orthologue of E. coli yebI (ZNUB_ECOLI); Fasta hit to ZNUB_ECOLI (261 aa), 96% identity in 261 aa overlap; Contains hydrophobic, probable membrane-spanning regions.
   
  
 0.498
sitC
Iron transport protein, inner membrane component; Similar to Salmonella typhimurium SitC an iron transport protein located on centisome 63 pathogenicity island TR:Q9XCS0 (EMBL:AF128999) (286 aa) fasta scores: E(): 0, 99.7% id in 286 aa and to Yersinia pestis chelated iron transport system membrane protein YfeC SW:YFEC_YERPE (Q56954) (294 aa) fasta scores: E(): 0, 66.5% id in 281 aa. Contains multiple possible membrane spanning hydrophobic domains.
   
  
 0.498
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.