node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0516 | STY1299 | gene:17584538 | gene:17585262 | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | 0.922 |
STY0516 | STY1745 | gene:17584538 | gene:17585680 | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.743 |
STY0516 | STY2920 | gene:17584538 | gene:17586814 | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | DNA-binding protein StpA; A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity). | 0.933 |
STY0516 | STY3527 | gene:17584538 | gene:17587376 | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | Conserved hypothetical protein; Orthologue of E. coli yhcB (YHCB_ECOLI); Fasta hit to YHCB_ECOLI (134 aa), 96% identity in 132 aa overlap. | 0.404 |
STY0516 | lppB | gene:17584538 | gene:17585681 | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.763 |
STY1299 | STY0516 | gene:17585262 | gene:17584538 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap. | 0.922 |
STY1299 | STY1342 | gene:17585262 | gene:17585302 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | 0.620 |
STY1299 | STY1661 | gene:17585262 | gene:17585596 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Conserved hypothetical protein; Binds to H-NS and modified the range of genes it silences; H- NS alonge silences core gene while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer. Plays a role silencing virulence factors in the absence of factors that induce pathogenicity (By similarity). The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC (By similarity); Belongs to the Hha/YmoA/Cnu family. | 0.828 |
STY1299 | STY1745 | gene:17585262 | gene:17585680 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.802 |
STY1299 | STY2845 | gene:17585262 | gene:17586735 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | CDP-diacylglycerol-serine O-phosphatidyltransferase; Orthologue of E. coli pssA (PSS_ECOLI); Fasta hit to PSS_ECOLI (451 aa), 94% identity in 451 aa overlap. | 0.483 |
STY1299 | STY2920 | gene:17585262 | gene:17586814 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | DNA-binding protein StpA; A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity). | 0.552 |
STY1299 | STY3527 | gene:17585262 | gene:17587376 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Conserved hypothetical protein; Orthologue of E. coli yhcB (YHCB_ECOLI); Fasta hit to YHCB_ECOLI (134 aa), 96% identity in 132 aa overlap. | 0.722 |
STY1299 | STY3782 | gene:17585262 | gene:17587646 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.711 |
STY1299 | STY3883 | gene:17585262 | gene:17587740 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Thiol:disulfide interchange protein; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily. | 0.571 |
STY1299 | lppB | gene:17585262 | gene:17585681 | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.794 |
STY1342 | STY1299 | gene:17585302 | gene:17585262 | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). | 0.620 |
STY1342 | STY1745 | gene:17585302 | gene:17585680 | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.632 |
STY1342 | STY2920 | gene:17585302 | gene:17586814 | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | DNA-binding protein StpA; A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity). | 0.542 |
STY1342 | STY3782 | gene:17585302 | gene:17587646 | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.657 |
STY1342 | lppB | gene:17585302 | gene:17585681 | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. | Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family. | 0.497 |