STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2920DNA-binding protein StpA; A DNA-binding protein that acts in a fashion similar to H-NS, repressing gene transcription. A subset of H-NS/StpA-regulated genes require auxillary proteins for repression; these auxillary proteins (Hha and other similar proteins) may also modulate oligomerization of the H-NS/StpA complex (By similarity). (133 aa)    
Predicted Functional Partners:
STY0516
Haemolysin expression modulating protein; Fasta hit to YDGT_ECOLI (71 aa), 38% identity in 71 aa overlap; Orthologue of E. coli hha (HHA_ECOLI); Fasta hit to HHA_ECOLI (72 aa), 99% identity in 72 aa overlap.
  
 
 0.933
STY1661
Conserved hypothetical protein; Binds to H-NS and modified the range of genes it silences; H- NS alonge silences core gene while the H-NS-Hha complex (and presumably also H-NS-YdgT) silences genes acquired by horizontal gene transfer. Plays a role silencing virulence factors in the absence of factors that induce pathogenicity (By similarity). The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC (By similarity); Belongs to the Hha/YmoA/Cnu family.
  
 
 
 0.911
STY3782
Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
  
    0.630
STY3527
Conserved hypothetical protein; Orthologue of E. coli yhcB (YHCB_ECOLI); Fasta hit to YHCB_ECOLI (134 aa), 96% identity in 132 aa overlap.
  
     0.557
STY1299
DNA-binding protein (histone-like protein Hlp-II); A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity).
  
 
  
0.552
STY1745
Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family.
  
    0.549
STY1342
Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.542
STY2845
CDP-diacylglycerol-serine O-phosphatidyltransferase; Orthologue of E. coli pssA (PSS_ECOLI); Fasta hit to PSS_ECOLI (451 aa), 94% identity in 451 aa overlap.
  
     0.530
lppB
Major outer membrane lipoprotein; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane; Belongs to the Lpp family.
  
    0.497
STY3883
Thiol:disulfide interchange protein; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily.
  
   
 0.495
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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