STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2963Putative rubredoxin reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (377 aa)    
Predicted Functional Partners:
STY2962
Putative flavoprotein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family.
   
 0.994
STY4484
Similar to Escherichia coli formate dehydrogenase H FdhF SW:FDHF_ECOLI (P07658) (715 aa) fasta scores: E(): 0, 97.5% id in 714 aa, and to Methanobacterium thermoformicicum formate dehydrogenase, alpha subunit FdhA TR:Q50569 (EMBL:U52681) (681 aa) fasta scores: E(): 0, 41.9% id in 688 aa. The CDS contains an opal UGA stop codon at position 140. In E. coli the nonsense mutation is supressed by the addition of the non standard amino acid, selenocysteine. Upstream of the opal codon there is a 20 bp stem loop structure; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
      0.907
STY2485
Probable nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
 
    
 0.900
STY2961
Putative sigma-54-dependent transriptional regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
 
   
 0.849
nirD
Nitrite reductase (NAD(P)H) small subunit; Required for activity of the reductase.
 
 0.800
hcr
NADH oxidoreductase Hcr; Similar to Escherichia coli NADH oxidoreductase Hcr SW:HCR_ECOLI (P75824) (322 aa) fasta scores: E(): 0, 89.1% id in 322 aa, and to Escherichia coli putative dioxygenase beta subunit YeaX yeaX SW:YEAX_ECOLI (P76254) (321 aa) fasta scores: E(): 2e-15, 26.8% id in 325 aa, and to Pseudomonas putida phthalate 4,5-dioxygenase oxygenase reductase subunit pht2 SW:PHT2_PSEPU (Q05182) (324 aa) fasta scores: E(): 9.1e-15, 26.8% id in 291 aa; Orthologue of E. coli HCR_ECOLI; Fasta hit to HCR_ECOLI (322 aa), 89% identity in 322 aa overlap.
 
 
 0.678
STY3510
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 95.4% id in 1486 aa and to Pseudomonas aeruginosa glutamate synthase large subunit GltB TR:P95456 (EMBL:U81261) (1482 aa) fasta scores: E(): 0, 60.9% id in 1476 aa.
     
 0.662
STY2784
Ferredoxin; Orthologue of E. coli fdx (FER_ECOLI); Fasta hit to FER_ECOLI (110 aa), 95% identity in 110 aa overlap.
  
 
 0.661
STY2287
phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; Similar to Salmonella typhimurium histidine biosynthesis bifunctional protein HisI [includes: phosphoribosyl-AMP cyclohydrolase hisI SW:HIS2_SALTY (P10367) (203 aa) fasta scores: E(): 0, 97.5% id in 203 aa; Orthologue of E. coli hisI (HIS2_ECOLI); Fasta hit to HIS2_ECOLI (203 aa), 91% identity in 203 aa overlap; In the C-terminal section; belongs to the PRA-PH family.
  
    0.643
STY2081
Similar to Xanthomonas campestris copper resistance protein C precursor SW:COPC_XANCJ (Q56797) (127 aa) fasta scores: E(): 1.6e-09, 34.7% id in 118 aa, and to Escherichia coli copper resistance protein C precursor pcoC SW:COPC_ECOLI (Q47454) (126 aa) fasta scores: E(): 2.9e-08, 41.1% id in 112 aa. Contains a probable N-terminal signal sequence; Orthologue of E. coli YOBA_ECOLI; Fasta hit to YOBA_ECOLI (124 aa), 73% identity in 124 aa overlap.
    
   0.597
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.