node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
invA | invG | gene:17586913 | gene:17586915 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | 0.995 |
invA | prgH | gene:17586913 | gene:17586891 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. | 0.996 |
invA | sigD | gene:17586913 | gene:17585096 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Cell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...] | 0.901 |
invA | sipA | gene:17586913 | gene:17586899 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family. | 0.913 |
invA | sipB | gene:17586913 | gene:17586902 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...] | 0.928 |
invA | sipC | gene:17586913 | gene:17586901 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity). | 0.919 |
invA | sipD | gene:17586913 | gene:17586900 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity island 1 effector protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC (By similarity). | 0.768 |
invA | spaN | gene:17586913 | gene:17586909 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Surface presentation of antigens protein (associated with type III secretion and virulence); Highly similar to Salmonella typhimurium surface presentation of antigens protein SpaN SW:SPAN_SALTY (P40613) (336 aa) fasta scores: E(): 0, 98.2% id in 336 aa. | 0.993 |
invA | spaT | gene:17586913 | gene:17586903 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity). | 0.914 |
invA | stpA | gene:17586913 | gene:17586895 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Tyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity). | 0.499 |
invG | invA | gene:17586915 | gene:17586913 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | 0.995 |
invG | prgH | gene:17586915 | gene:17586891 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Pathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. | 0.999 |
invG | sigD | gene:17586915 | gene:17585096 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Cell invasion protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicl [...] | 0.706 |
invG | sipA | gene:17586915 | gene:17586899 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Pathogenicity island 1 effector protein (function unknown); Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F- actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization (By similarity). Belongs to the SipA/IpaA family. | 0.984 |
invG | sipB | gene:17586915 | gene:17586902 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Pathogenicity island 1 effector protein; Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in associat [...] | 0.921 |
invG | sipC | gene:17586915 | gene:17586901 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Pathogenicity island 1 effector protein; Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity). | 0.955 |
invG | sipD | gene:17586915 | gene:17586900 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Pathogenicity island 1 effector protein; Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC (By similarity). | 0.969 |
invG | spaN | gene:17586915 | gene:17586909 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Surface presentation of antigens protein (associated with type III secretion and virulence); Highly similar to Salmonella typhimurium surface presentation of antigens protein SpaN SW:SPAN_SALTY (P40613) (336 aa) fasta scores: E(): 0, 98.2% id in 336 aa. | 0.998 |
invG | spaT | gene:17586915 | gene:17586903 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity). | 0.987 |
invG | stpA | gene:17586915 | gene:17586895 | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | Tyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity). | 0.909 |