Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| invA | invE | gene:17586913 | gene:17586914 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | 0.996 |
| invA | invG | gene:17586913 | gene:17586915 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | 0.995 |
| invA | prgH | gene:17586913 | gene:17586891 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Pathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. | 0.996 |
| invA | spaI | gene:17586913 | gene:17586911 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory apparatus ATP synthase (associated with virulence); Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells (By similarity). | 0.999 |
| invA | spaM | gene:17586913 | gene:17586910 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Similar to Salmonella typhimurium surface presentation of antigens protein spaM SW:SPAM_SALTY (P40612) (147 aa) fasta scores: E(): 0, 99.3% id in 147 aa. Contains possible coiled-coils between residues 75..110. | 0.967 |
| invA | spaN | gene:17586913 | gene:17586909 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Surface presentation of antigens protein (associated with type III secretion and virulence); Highly similar to Salmonella typhimurium surface presentation of antigens protein SpaN SW:SPAN_SALTY (P40613) (336 aa) fasta scores: E(): 0, 98.2% id in 336 aa. | 0.993 |
| invA | spaP | gene:17586913 | gene:17586907 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliP/MopC/SpaP family. | 0.999 |
| invA | spaS | gene:17586913 | gene:17586904 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Similar to Salmonella typhimurium surface presentation of antigens protein SpaS SW:SPAS_SALTY (P40702) (356 aa) fasta scores: E(): 0, 99.4% id in 356 aa. Contains possible membrane spanning hydrophobic domains. | 0.999 |
| invA | spaT | gene:17586913 | gene:17586903 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity). | 0.914 |
| invA | spak | gene:17586913 | gene:17586912 | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | Secretory protein (associated with virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. | 0.896 |
| invE | invA | gene:17586914 | gene:17586913 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Possible secretory protein (associated with virulence); Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein (By similarity); Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. | 0.996 |
| invE | invG | gene:17586914 | gene:17586915 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory protein (associated with virulence); Highly similar to Salmonella typhimurium InvG protein precursor SW:INVG_SALTY (P35672) (562 aa) fasta scores: E(): 0, 99.1% id in 562 aa and to Shigella flexneri outer membrane protein MxiD SW:MXID_SHIFL (Q04641) (566 aa) fasta scores: E(): 0, 50.9% id in 489 aa. Contains a possible N-terminal signal sequence. | 0.996 |
| invE | prgH | gene:17586914 | gene:17586891 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Pathogenicity 1 island effector protein; Similar to Salmonella typhimurium protein PrgH required for invasion of epithelial cells SW:PRGH_SALTY (P41783) (392 aa) fasta scores: E(): 0, 99.2% id in 392 aa. Contains possible membrane spanning hydrophobic domains. | 0.954 |
| invE | spaI | gene:17586914 | gene:17586911 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory apparatus ATP synthase (associated with virulence); Necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase. May energize the protein export apparatus encoded in the inv locus which is required for the surface presentation of determinants needed for the entry of salmonella species into mammalian cells (By similarity). | 0.995 |
| invE | spaM | gene:17586914 | gene:17586910 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory protein (associated with virulence); Similar to Salmonella typhimurium surface presentation of antigens protein spaM SW:SPAM_SALTY (P40612) (147 aa) fasta scores: E(): 0, 99.3% id in 147 aa. Contains possible coiled-coils between residues 75..110. | 0.987 |
| invE | spaN | gene:17586914 | gene:17586909 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Surface presentation of antigens protein (associated with type III secretion and virulence); Highly similar to Salmonella typhimurium surface presentation of antigens protein SpaN SW:SPAN_SALTY (P40613) (336 aa) fasta scores: E(): 0, 98.2% id in 336 aa. | 0.996 |
| invE | spaP | gene:17586914 | gene:17586907 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory protein (associated with virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the FliP/MopC/SpaP family. | 0.987 |
| invE | spaS | gene:17586914 | gene:17586904 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory protein (associated with virulence); Similar to Salmonella typhimurium surface presentation of antigens protein SpaS SW:SPAS_SALTY (P40702) (356 aa) fasta scores: E(): 0, 99.4% id in 356 aa. Contains possible membrane spanning hydrophobic domains. | 0.986 |
| invE | spaT | gene:17586914 | gene:17586903 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Unknown function; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity). | 0.921 |
| invE | spak | gene:17586914 | gene:17586912 | Cell invasion protein; Involved in the triggering of intracellular events that lead to microbial internalization. These events include increase in calcium level, redistribution of actin microfilaments, and changes in the normal structure of the microvilli. Encoded within the type III secretion system (SPI-1 TTSS), it is essential for the translocation of protein effectors into host cells. Forms a complex with SipB and SipC in the presence of their chaperone SicA (By similarity). | Secretory protein (associated with virulence); Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. | 0.910 |
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