STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3033DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity). (855 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.996
STY3941
DNA polymerase III beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.965
STY3881
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.908
STY3111
5'-3' exonuclease; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
   
 0.799
recQ
Similar to Escherichia coli ATP-dependent DNA helicase RecQ SW:RECQ_ECOLI (P15043; P76762) (607 aa) fasta scores: E(): 0, 94.6% id in 608 aa.
  
 0.665
radC
Similar to Escherichia coli DNA repair protein RadC radC SW:RADC_ECOLI (P25531) (222 aa) fasta scores: E(): 0, 83.7% id in 215 aa, and to Haemophilus influenzae DNA repair protein SW:RADC_HAEIN (P44952) (234 aa) fasta scores: E(): 0, 51.2% id in 217 aa; Belongs to the UPF0758 family. YicR subfamily.
 
   
 0.648
STY1804
Conserved hypothetical protein; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity).
     
 0.569
STY3198
Single-stranded DNA-specific exonuclease; Orthologue of E. coli recJ (RECJ_ECOLI); Fasta hit to RECJ_ECOLI (577 aa), 91% identity in 577 aa overlap.
 
  
 0.566
STY1419
Similar to Escherichia coli probable pyruvate-flavodoxin oxidoreductase ydbK SW:NIFJ_ECOLI (P52647; P77238) (1174 aa) fasta scores: E(): 0, 92.9% id in 1174 aa; Orthologue of E. coli NIFJ_ECOLI; Fasta hit to NIFJ_ECOLI (1174 aa), 93% identity in 1174 aa overlap.
  
    0.545
STY3775
Primosomal protein replication factor; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
     0.536
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.