STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
STY30743'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite. (244 aa)    
Predicted Functional Partners:
cysC
Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate.
 0.999
cysN
ATP sulfurylase (ATP:sulfate adenyltransferase) subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
 0.999
STY3075
Sulfite reductase (NADPH) hemoprotein alpha subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
 0.999
STY3076
Sulfite reductase (NADPH) flavoprotein beta subunit; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
 
 
 0.999
STY2678
Sulphate transport ATP-binding protein CysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
  
  
 0.995
cysD
ATP sulfurylase (ATP:sulfate adenyltransferase); Orthologue of E. coli cysD (CYSD_ECOLI); Fasta hit to CYSD_ECOLI (302 aa), 97% identity in 302 aa overlap.
 
  
 0.995
STY2679
Sulphate transport system permease protein CysW; Fasta hit to CYST_ECOLI (277 aa), 37% identity in 259 aa overlap; Orthologue of E. coli cysW (CYSW_ECOLI); Fasta hit to CYSW_ECOLI (291 aa), 97% identity in 291 aa overlap.
  
  
 0.983
cysQ
cysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.
  
 
 0.980
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.966
STY2681
Similar to Salmonella typhimurium thiosulphate-binding protein precursor cysP SW:CYSP_SALTY (P41031) (338 aa) fasta scores: E(): 0, 97.3% id in 338 aa; Fasta hit to SUBI_ECOLI (329 aa), 47% identity in 320 aa overlap; Orthologue of E. coli cysP (CYSP_ECOLI); Fasta hit to CYSP_ECOLI (338 aa), 94% identity in 337 aa overlap.
  
  
 0.936
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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