STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STY3203Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well. (88 aa)    
Predicted Functional Partners:
STY3202
Conserved hypothetical protein; Orthologue of E. coli YGFX_ECOLI; Fasta hit to YGFX_ECOLI (135 aa), 82% identity in 113 aa overlap.
  
  
 0.855
STY0775
Succinate dehydrogenase cytochrome b-556 subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
   
 0.713
STY2664
Cell division protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
  
     0.699
STY0777
Succinate dehydrogenase flavoprotein subunit; Fasta hit to NADB_ECOLI (540 aa), 32% identity in 570 aa overlap; Fasta hit to FRDA_ECOLI (601 aa), 43% identity in 597 aa overlap; Orthologue of E. coli sdhA (DHSA_ECOLI); Fasta hit to DHSA_ECOLI (588 aa), 98% identity in 588 aa overlap; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 
 0.698
frdA
Similar to Escherichia coli fumarate reductase flavoprotein subunit SW:FRDA_ECOLI (P00363) (601 aa) fasta scores: E(): 0, 95.3% id in 594 aa, and to Proteus vulgaris fumarate reductase flavoprotein subunit frdA SW:FRDA_PROVU (P20922) (598 aa) fasta scores: E(): 0, 85.5% id in 598 aa.
  
 
 0.668
STY1334
Putative protease; Orthologue of E. coli sohB (SOHB_ECOLI); Fasta hit to SOHB_ECOLI (349 aa), 87% identity in 349 aa overlap.
  
     0.648
STY0729
Similar to Salmonella typhi plasmid R27 hypothetical protein r0146 TR:Q9L5J6 (EMBL:AF250878) (467 aa) fasta scores: E(): 0, 93.1% id in 467 aa, and to Rhodobacter capsulatus hypothetical 86.4 kDa protein TR:O68107 (EMBL:AF010496) (828 aa) fasta scores: E(): 0, 37.8% id in 465 aa, and to Caenorhabditis elegans hypothetical 50.0 kDa protein F48e8.3 in chromosome iii f48e8.3 TR:Q09567 (EMBL:U23514) (474 aa) fasta scores: E(): 5.2e-07, 24.7% id in 478 aa.
  
 
 0.642
STY1823
Similar to Escherichia coli hypothetical 10.3 kDa protein in ansA-gapA intergenic region yeaC SW:YEAC_ECOLI (P76231) (90 aa) fasta scores: E(): 9.2e-33, 87.8% id in 90 aa, and to Alteromonas haloplanktis hypothetical 10.6 kDa protein in daga 3'region SW:YEAC_ALTHA (P56607) (93 aa) fasta scores: E(): 3.1e-13, 44.3% id in 79 aa.
  
     0.629
STY3204
Conserved hypothetical protein; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family.
 
     0.605
STY0776
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
     0.590
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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