STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3462Conserved hypothetical protein; May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity). (294 aa)    
Predicted Functional Partners:
STY1976
Tail-specific protease precursor; Orthologue of E. coli prc (PRC_ECOLI); Fasta hit to PRC_ECOLI (682 aa), 93% identity in 682 aa overlap; Belongs to the peptidase S41A family.
  
 
 
 0.891
STY4808
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.774
proP
ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family.
  
   
 0.757
STY3496
Possible exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
   
 0.749
STY2465
Conserved hypothetical protein; Orthologue of E. coli yejL (YEJL_ECOLI); Fasta hit to YEJL_ECOLI (75 aa), 91% identity in 75 aa overlap; Belongs to the UPF0352 family.
  
     0.739
STY3106
Syd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family.
  
     0.736
STY0735
seqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.735
STY3770
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family.
  
     0.728
STY2856
Chorismate mutase/prephenate dehydrogenase; Orthologue of E. coli tyrA (TYRA_ECOLI); Fasta hit to TYRA_ECOLI (373 aa), 95% identity in 372 aa overlap.
 
     0.704
STY2566
Similar to Vibrio cholerae hypothetical protein VC1099 TR:Q9KT06 (EMBL:AE004191) (152 aa) fasta scores: E(): 1.1e-24, 46.6% id in 146 aa and Haemophilus influenzae hypothetical protein HIL205 SW:YC05_HAEIN (P44127) (147 aa) fasta scores: E(): 7.5e-22, 44.1% id in 145 aa; Orthologue of E. coli P77496; Fasta hit to P77496 (151 aa), 95% identity in 151 aa overlap.
  
     0.702
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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