STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3474Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (644 aa)    
Predicted Functional Partners:
hflC
HflC protein; HflC and HflK could regulate a protease.
  
 0.983
hflK
HflK protein; HflC and HflK could encode or regulate a protease.
  
 0.979
STY3475
Cell division protein; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
 
  
 0.859
rpsE
30S ribosomal subunit protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
  
 
 0.797
STY1159
Proline dehydrogenase (proline oxidase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
      
 0.785
STY0547
Putative membrane protein; Similar to Escherichia coli hypothetical 33.7 kDa protein in usha-tesa intergenic region ybbK SW:YBBK_ECOLI (P77367) (305 aa) fasta scores: E(): 0, 94.7% id in 304 aa, and to Mycobacterium tuberculosis hypothetical 41.2 kDa protein rv1488 rv1488 or mtcy277.09 SW:YE88_MYCTU (P71768) (381 aa) fasta scores: E(): 0, 38.7% id in 310 aa; Orthologue of E. coli YBBK_ECOLI; Fasta hit to YBBK_ECOLI (305 aa), 95% identity in 304 aa overlap.
   
 0.784
STY0192
Hypoxanthine phosphoribosyltransferase; Orthologue of E. coli hpt (HPRT_ECOLI); Fasta hit to HPRT_ECOLI (182 aa), 95% identity in 171 aa overlap; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.775
rplB
50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
 
 0.770
STY2860
50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
 
   0.768
rplC
50S ribosomal subunit protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
  
 
 0.765
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.