STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity). (253 aa)    
Predicted Functional Partners:
STY2413
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
 
 
 0.988
deoA
Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
  
 
 0.951
STY2335
Uridine kinase; Orthologue of E. coli udk (URK_ECOLI); Fasta hit to URK_ECOLI (213 aa), 96% identity in 213 aa overlap.
    
 0.930
deoD
Similar to Escherichia coli purine nucleoside phosphorylase deod or puP SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 97.1% id in 238 aa.
 
  
0.930
STY2416
Putative oxidoreductase; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6-dihydrothymine (DHT) (By similarity).
 
  
  0.915
STY3644
Similar to Klebsiella aerogenes uridine phosphorylase UDP SW:UDP_KLEAE (O08444) (253 aa) fasta scores: E(): 2.1e-23, 39.4% id in 218 aa, and to Escherichia coli uridine phosphorylase UDP SW:UDP_ECOLI (P12758) (252 aa) fasta scores: E(): 4.5e-23, 38.5% id in 218 aa; Fasta hit to DEOD_ECOLI (238 aa), 34% identity in 203 aa overlap; Paralogue of E. coli udp (UDP_ECOLI); Fasta hit to UDP_ECOLI (252 aa), 39% identity in 218 aa overlap.
  
  
 
0.914
STY2739
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
     
 0.912
STY1301
Thymidine kinase; Orthologue of E. coli tdk (KITH_ECOLI); Fasta hit to KITH_ECOLI (205 aa), 93% identity in 204 aa overlap.
     
 0.911
STY3514
Cytosine deaminase; Orthologue of E. coli codA (CODA_ECOLI); Fasta hit to CODA_ECOLI (426 aa), 84% identity in 426 aa overlap.
    
 0.908
STY0424
Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
     
 0.906
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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