STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
STY3595Trans-activator of metE and metH; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression (By similarity). Belongs to the LysR transcriptional regulatory family. (317 aa)    
Predicted Functional Partners:
STY3761
5,10 methylenetetrahydrofolate reductase; Orthologue of E. coli metF (METF_ECOLI); Fasta hit to METF_ECOLI (296 aa), 96% identity in 296 aa overlap; Belongs to the methylenetetrahydrofolate reductase family.
   
  
 0.969
STY3594
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
  
 0.962
STY3769
Cystathionine gamma-synthase; Fasta hit to METC_ECOLI (395 aa), 31% identity in 394 aa overlap; Orthologue of E. coli metB (METB_ECOLI); Fasta hit to METB_ECOLI (386 aa), 96% identity in 386 aa overlap.
   
  
 0.903
STY3770
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family.
   
  
 0.895
STY0647
Putative aminotransferase; Similar to Escherichia coli hypothetical aminotransferase YbdL ybdL SW:YBDL_ECOLI (P77806) (386 aa) fasta scores: E(): 0, 85.2% id in 386 aa, and to Thermus aquaticus aspartate aminotransferase aspC SW:AAT_THETH (Q56232) (385 aa) fasta scores: E(): 3e-31, 32.2% id in 379 aa; Orthologue of E. coli YBDL_ECOLI; Fasta hit to YBDL_ECOLI (386 aa), 85% identity in 386 aa overlap.
   
  
 0.866
STY3891
Ribose operon repressor; Fasta hit to CYTR_ECOLI (341 aa), 36% identity in 332 aa overlap; Fasta hit to PURR_ECOLI (340 aa), 46% identity in 332 aa overlap; Fasta hit to GALR_ECOLI (343 aa), 32% identity in 332 aa overlap; Fasta hit to LACI_ECOLI (360 aa), 32% identity in 328 aa overlap; Orthologue of E. coli rbsR (RBSR_ECOLI); Fasta hit to RBSR_ECOLI (329 aa), 90% identity in 330 aa overlap.
      
 0.610
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
   
    0.572
STY3944
Putative LysR-family transcriptioanl regulator; Weakly similar to many transcriptional regulators including: Escherichia coli hypothetical transcriptional regulator YfeR SW:YFER_ECOLI (P77500) (308 aa) fasta scores: E(): 9.6e-17, 26.4% id in 311 aa, and to Escherichia coli cyn operon transcriptional activator CynR SW:CYNR_ECOLI (P27111) (299 aa) fasta scores: E(): 2.1e-11, 26.3% id in 297 aa; Belongs to the LysR transcriptional regulatory family.
  
     0.556
STY3708
Possible LysR-family transcriptional regulatory protein; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.
  
     0.545
STY3333
Beta-cystathionase; Fasta hit to METB_ECOLI (386 aa), 32% identity in 398 aa overlap; Orthologue of E. coli metC (METC_ECOLI); Fasta hit to METC_ECOLI (395 aa), 87% identity in 395 aa overlap.
   
  
 0.534
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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