STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfiPutative endonuclease; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa)    
Predicted Functional Partners:
STY3718
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
    0.878
STY1753
Conserved hypothetical protein; Orthologue of E. coli YNHE_ECOLI; Fasta hit to YNHE_ECOLI (495 aa), 96% identity in 495 aa overlap.
     
 0.812
STY3716
Conserved hypothetical protein; Orthologue of E. coli YjaG (YJAG_ECOLI); Fasta hit to YJAG_ECOLI (196 aa), 95% identity in 196 aa overlap; To H.influenzae HI_0431.
  
    0.778
STY3719
Conserved hypothetical protein; Orthologue of E. coli yjaD (YJAD_ECOLI); Fasta hit to YJAD_ECOLI (257 aa), 92% identity in 257 aa overlap.
       0.652
STY2084
Orthologue of E. coli EXOX_ECOLI; Fasta hit to EXOX_ECOLI (220 aa), 91% identity in 219 aa overlap.
      
 0.471
rsD
Putative regulatory protein; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
       0.464
STY2337
DNA-3-methyladenine glycosidase II; Orthologue of E. coli alkA (3MG2_ECOLI); Fasta hit to 3MG2_ECOLI (282 aa), 74% identity in 279 aa overlap.
      
 0.463
STY3715
Histone like DNA-binding protein HU-alpha (NS2) (HU-2); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family.
   
   0.451
STY3714
Conserved hypothetical protein; Orthologue of E. coli yjaH (YJAH_ECOLI); Fasta hit to YJAH_ECOLI (231 aa), 77% identity in 231 aa overlap.
       0.422
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.