STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STY3725Thiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.999
STY3726
Thiamine biosynthesis protein; Orthologue of E. coli thiH (THIH_ECOLI); Fasta hit to THIH_ECOLI (377 aa), 90% identity in 375 aa overlap.
 
 0.999
STY3721
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.996
thiS
Thiamine biosynthesis protein; Similar to Escherichia coli this protein ThiS SW:THIS_ECOLI (O32583) (66 aa) fasta scores: E(): 6.5e-19, 77.3% id in 66 aa. Note, due to overlap, the translational start site differs from that of E. coli.
  
 
 0.996
STY3723
Thiamine biosynthesis protein; Fasta hit to MOEB_ECOLI (249 aa), 45% identity in 245 aa overlap; Orthologue of E. coli thiF (THIF_ECOLI); Fasta hit to THIF_ECOLI (251 aa), 87% identity in 251 aa overlap.
 
  
 0.995
STY0464
Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 
 0.975
thiD
Phosphomethylpyrimidine kinase; Similar to Salmonella typhimurium LT2 phosphomethylpyrimidine kinase SW:THID_SALTY (P55882) (266 aa) fasta scores: E(): 0, 99.2% id in 266 aa; Orthologue of E. coli THID_ECOLI; Fasta hit to THID_ECOLI (266 aa), 91% identity in 266 aa overlap.
 
  
 0.960
dxs
1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.933
STY0884
Molybdopterin biosynthesis MoeB protein; Fasta hit to THIF_ECOLI (251 aa), 43% identity in 245 aa overlap; Orthologue of E. coli moeB (MOEB_ECOLI); Fasta hit to MOEB_ECOLI (249 aa), 89% identity in 249 aa overlap.
 
  
 0.854
STY0839
Molybdopterin converting factor, subunit 1; Orthologue of E. coli moaD (MOAD_ECOLI); Fasta hit to MOAD_ECOLI (81 aa), 85% identity in 81 aa overlap.
   
 
 0.704
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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