STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY3826Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (489 aa)    
Predicted Functional Partners:
STY3827
L-rhamnose isomerase; Orthologue of E. coli rhaA (RHAA_ECOLI); Fasta hit to RHAA_ECOLI (419 aa), 94% identity in 418 aa overlap.
 
 
 0.999
STY3831
Conserved hypothetical protein; Involved in the anomeric conversion of L-rhamnose.
 
  
 0.942
STY3824
L-rhamnose operon transcriptional activator; Activates expression of the rhaSR operon in response to L- rhamnose.
 
  
 0.939
STY3825
L-rhamnose operon regulatory protein; Activates expression of the rhaBAD and rhaT operons.
 
  
 0.924
STY4122
Putative L-xylulose kinase; Orthologue of E. coli lyxK (LYXK_ECOLI); Fasta hit to LYXK_ECOLI (498 aa), 86% identity in 498 aa overlap.
  
  
 
0.904
STY3823
L rhamnose-proton symporter; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
 
  
 0.902
STY0120
L-ribulokinase; Orthologue of E. coli araB (KIRI_ECOLI); Fasta hit to KIRI_ECOLI (565 aa), 90% identity in 567 aa overlap.
  
  
 0.865
STY0118
L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
  
  
 0.844
STY4060
RNase PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
      
 0.799
STY3116
L-fuculose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose.
 
  
 0.738
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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