STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nikRNickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. (133 aa)    
Predicted Functional Partners:
STY3168
Conserved hypothetical protein; Highly similar to many proteins of undefined function e.g. Escherichia coli YohL SW:YOHL_ECOLI (P76424) (90 aa) fasta scores: E(): 1.3e-32, 93.3% id in 90 aa and to Serratia marcescens SW:YOHL_SERMA (P55757) (91 aa) fasta scores: E(): 2.6e-15, 51.6% id in 91 aa; Fasta hit to YAIN_ECOLI (91 aa), 40% identity in 92 aa overlap; Orthologue of E. coli YOHL_ECOLI; Fasta hit to YOHL_ECOLI (90 aa), 93% identity in 90 aa overlap.
      
 0.816
STY2976
HypA protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
     
 0.728
STY3741
Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
     
 0.681
STY2977
Hydrogenase isoenzymes formation protein HypB; Orthologue of E. coli hypB (HYPB_ECOLI); Fasta hit to HYPB_ECOLI (290 aa), 95% identity in 290 aa overlap.
 
   
 0.660
STY0812
Putative molybdenum transport protein ModE; Orthologue of E. coli modE (MODE_ECOLI); Fasta hit to MODE_ECOLI (262 aa), 89% identity in 262 aa overlap.
      
 0.589
zur
Similar to Escherichia coli zinc uptake regulation protein zur SW:ZUR_ECOLI (P32692) (171 aa) fasta scores: E(): 0, 93.0% id in 171 aa, and to Neisseria meningitidis zinc uptake regulation protein NMB1266 TR:AAF41643 (EMBL:AE002475) (158 aa) fasta scores: E(): 4.6e-07, 30.6% id in 160 aa; Belongs to the Fur family.
   
  
 0.565
STY4228
Conserved hypothetical protein; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis. The native apo- protein substrate is unknown; Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
       0.541
STY1320
Conserved hypothetical protein; Similar to Salmonella typhimurium putative catalase TR:CAB76676 (EMBL:Y19180) (292 aa) fasta scores: E(): 0, 99.3% id in 292 aa, and to Bacillus subtilis general stress protein 80 ydbD SW:GS80_BACSU (P80878; P96599) (273 aa) fasta scores: E(): 3.7e-21, 33.1% id in 251 aa.
      
 0.504
zntR
Putative Zn(II)-responsive regulator; Similar to Escherichia coli zn zntR SW:ZNTR_ECOLI (P36676) (141 aa) fasta scores: E(): 0, 92.9% id in 141 aa.
      
 0.471
cueR
Copper efflux regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity).
      
 0.459
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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