STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yheLConserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. (95 aa)    
Predicted Functional Partners:
yheM
Conserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
 
 0.999
yheN
Conserved hypothetical protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.
 
 
 0.998
STY1111
Hypothetical protein in helD-serT intergenic region; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD (By similarity).
 
 
 0.932
yheO
Similar to Escherichia coli hypothetical 26.8 kDa protein in rpsl-fkpa intergenic region yheO SW:YHEO_ECOLI (P45533) (240 aa) fasta scores: E(): 0, 97.9% id in 240 aa, and to Haemophilus influenzae hypothetical protein Hi0575 hi0575 SW:YHEO_HAEIN (P44761) (221 aa) fasta scores: E(): 0, 67.6% id in 219 aa; Orthologue of E. coli YHEO_ECOLI; Fasta hit to YHEO_ECOLI (240 aa), 98% identity in 240 aa overlap.
 
   
 0.839
STY1283
Conserved hypothetical protein; Similar to Klebsiella pneumoniae YchN protein ychN TR:Q9RLW1 (EMBL:L27824) (117 aa) fasta scores: E(): 0, 92.3% id in 117 aa; Orthologue of E. coli ychN (YCHN_ECOLI); Fasta hit to YCHN_ECOLI (117 aa), 92% identity in 117 aa overlap.
  
 
 0.779
STY3488
Possible anti-sigma factor antagonist; Similar to the C-terminus of Escherichia coli hypothetical 14.4 kDa protein in YrbB SW:YRBB_ECOLI (P45389) (129 aa) fasta scores: E(): 1.3e-25, 69.1% id in 97 aa. Also similar to several anti-sigma factor antagonists e.g. Listeria monocytogenes anti-sigma B factor antagonist RsbV SW:RSBV_LISMO (O85016) (114 aa) fasta scores: E(): 0.38, 25.6% id in 90 aa.
  
     0.634
STY1274
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family.
     
 0.632
STY3906
ATP synthase protein I; Orthologue of E. coli atpI (ATPZ_ECOLI); Fasta hit to ATPZ_ECOLI (125 aa), 91% identity in 124 aa overlap. Contains possible membrane spanning hydrophobic domains.
  
     0.626
STY0789
Putative membrane protein; Similar to Escherichia coli 10.9 kDa protein in cydb-tolq intergenic region SW:YBGE_ECOLI (P37343) (97 aa) fasta scores: E(): 0, 86.7% id in 90 aa, and to Vibrio cholerae hypothetical protein Vc1841 vc1841 TR:Q9KR06 (EMBL:AE004260) (105 aa) fasta scores: E(): 1.2e-09, 38.5% id in 78 aa.
  
     0.625
yhhP
Conserved hypothetical protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
 
   
 0.592
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.