STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY4429Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa)    
Predicted Functional Partners:
STY4430
4-hydroxybenzoate octaprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
    
 0.986
menF
Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.
     
 0.931
STY0639
Isochorismate synthase EntC; Orthologue of E. coli entC (ENTC_ECOLI); Fasta hit to ENTC_ECOLI (391 aa), 85% identity in 388 aa overlap.
     
 0.906
STY2856
Chorismate mutase/prephenate dehydrogenase; Orthologue of E. coli tyrA (TYRA_ECOLI); Fasta hit to TYRA_ECOLI (373 aa), 95% identity in 372 aa overlap.
    
 0.864
STY2854
Chorismate mutase-P/prephenate dehydratase; Orthologue of E. coli pheA (PHEA_ECOLI); Fasta hit to PHEA_ECOLI (386 aa), 91% identity in 385 aa overlap.
    
 0.863
STY1327
Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
    
 0.830
STY1328
Anthranilate synthase component I; Orthologue of E. coli trpE (TRPE_ECOLI); Fasta hit to TRPE_ECOLI (520 aa), 90% identity in 520 aa overlap.
    
 0.819
aroQ
Putative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate.
    
 0.811
STY4444
Similar to Salmonella typhimurium aromatic-amino-acid aminotransferase SW:TYRB_SALTY (P74861) (397 aa) fasta scores: E(): 0, 98.0% id in 397 aa, and to Escherichia coli aromatic-amino-acid aminotransferase tyrB SW:TYRB_ECOLI (P04693) (397 aa) fasta scores: E(): 0, 88.9% id in 397 aa.
     
 0.804
STY1000
Aspartate aminotransferase; Fasta hit to TYRB_ECOLI (397 aa), 43% identity in 397 aa overlap; Orthologue of E. coli aspC (AAT_ECOLI); Fasta hit to AAT_ECOLI (396 aa), 96% identity in 396 aa overlap; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
     
  0.800
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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