STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sgaUConserved hypothetical protein; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the L-ribulose-5-phosphate 3-epimerase family. (284 aa)    
Predicted Functional Partners:
sgaH
Putative hexulose-6-phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily.
 
 
 0.999
sgaE
Probable class II aldolase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
  
 0.998
STY4121
Similar to Methylomonas aminofaciens hexulose-6-phosphate synthase hps SW:HUMS_METAM (Q48907) (208 aa) fasta scores: E(): 5.9e-17, 34.6% id in 205 aa; Fasta hit to SGAH_ECOLI (216 aa), 45% identity in 216 aa overlap; Orthologue of E. coli yiaQ (SGBH_ECOLI); Fasta hit to SGBH_ECOLI (220 aa), 90% identity in 220 aa overlap.
 
 
 0.994
sgaT
Putative transport protein SgaT; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
 
   
 0.987
sgaA
Probable sugar phosphotransferase; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
 
  
 0.981
sgaB
Putative PTS system IIB protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
 
  
 0.970
STY0118
L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).
  
 0.945
STY4119
Putative sugar isomerase; Similar to Salmonella typhimurium L-ribulose-5-phosphate 4-epimerase araD SW:ARAD_SALTY (P06190) (231 aa) fasta scores: E(): 0, 76.2% id in 231 aa; Fasta hit to SGAE_ECOLI (228 aa), 63% identity in 230 aa overlap; Fasta hit to ARAD_ECOLI (231 aa), 77% identity in 231 aa overlap; Orthologue of E. coli yiaS (SGBE_ECOLI); Fasta hit to SGBE_ECOLI (231 aa), 93% identity in 231 aa overlap.
  
 0.944
STY4122
Putative L-xylulose kinase; Orthologue of E. coli lyxK (LYXK_ECOLI); Fasta hit to LYXK_ECOLI (498 aa), 86% identity in 498 aa overlap.
 
 
 0.928
yjfR
Conserved hypothetical protein; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions; Belongs to the UlaG family.
 
   
 0.919
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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