STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cysQcysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa)    
Predicted Functional Partners:
STY3074
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase; Reduction of activated sulfate into sulfite.
  
 
 0.980
cysC
Adenosine 5-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate.
 
 
 0.972
cysD
ATP sulfurylase (ATP:sulfate adenyltransferase); Orthologue of E. coli cysD (CYSD_ECOLI); Fasta hit to CYSD_ECOLI (302 aa), 97% identity in 302 aa overlap.
 
 0.971
cysN
ATP sulfurylase (ATP:sulfate adenyltransferase) subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
 
 0.947
STY0008
Molybdopterin biosynthesis Mog protein; Orthologue of E. coli mog (MOG_ECOLI); Fasta hit to MOG_ECOLI (195 aa), 94% identity in 192 aa overlap.
   
  
 0.652
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
  
  
 0.638
STY2792
Extragenic suppressor protein SuhB; Fasta hit to CYSQ_ECOLI (246 aa), 31% identity in 233 aa overlap; Orthologue of E. coli suhB (SUHB_ECOLI); Fasta hit to SUHB_ECOLI (267 aa), 96% identity in 267 aa overlap; Belongs to the inositol monophosphatase superfamily.
 
   
0.500
STY1326
Indole-3-glycerol phosphate synthase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
   
  
 0.478
cpdB
Similar to Escherichia coli 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor cpdB SW:CN16_ECOLI (P08331) (647 aa) fasta scores: E(): 0, 90.3% id in 647 aa; Belongs to the 5'-nucleotidase family.
       0.461
STY3142
Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
    0.408
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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