STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0174Pyruvate dehydrogenase complex repressor; Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd. (254 aa)    
Predicted Functional Partners:
STY0175
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
  
 0.772
STY0176
Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
  
 0.747
treR
Similar to Escherichia coli trehalose operon repressor treR SW:TRER_ECOLI (P36673) (315 aa) fasta scores: E(): 0, 87.9% id in 315 aa.
    
 
 0.713
STY2839
Conserved hypothetical protein; Acts as a radical domain for damaged PFL and possibly other radical proteins.
      
 0.687
STY0177
Dihydrolipoamide dehydrogenase; Orthologue of E. coli lpdA (DLDH_ECOLI); Fasta hit to DLDH_ECOLI (473 aa), 98% identity in 473 aa overlap.
  
  
 0.643
STY4104
L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force (By similarity).
 
  
 0.624
STY3537
Possible transcriptional regulator; Similar to Streptomyces coelicolor putative GntR-family transcriptional regulator scgd3.11C TR:Q9XA67 (EMBL:AL096822) (216 aa) fasta scores: E(): 7.4e-11, 33.2% id in 189 aa.
  
  
 0.596
STY4201
gntR family regulatory protein; Similar to Bacillus subtilis YvoA TR:O34817 (EMBL:AF017113) (243 aa) fasta scores: E(): 1.9e-22, 31.9% id in 232 aa, and Bacillus subtilis hypothetical transcriptional regulator in hom-mrgA intergenic region YurK SW:YURK_BACSU (O32152) (242 aa) fasta scores: E(): 1.1e-20, 31.4% id in 236 aa.
  
    0.562
STY4136
Xylose operon regulatory protein; Orthologue of E. coli xylR (XYLR_ECOLI); Fasta hit to XYLR_ECOLI (392 aa), 92% identity in 392 aa overlap.
   
 
 0.545
STY3770
Repressor of the methionine regulon; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family.
  
   
 0.533
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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