STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY0620Oxygen-insensitive NAD(P)H nitroreductase; Orthologue of E. coli nfnB (NFNB_ECOLI); Fasta hit to NFNB_ECOLI (217 aa), 88% identity in 217 aa overlap. (217 aa)    
Predicted Functional Partners:
nfsA
Similar to Salmonella typhimurium oxygen-insensitive NADPH nitroreductase SW:NFSA_SALTY (Q9Z5Z2) (240 aa) fasta scores: E(): 0, 96.3% id in 240 aa, and to Escherichia coli oxygen-insensitive NADPH nitroreductase SW:NFSA_ECOLI (P17117) (240 aa) fasta scores: E(): 0, 87.5% id in 240 aa, and to Vibrio harveyi NADPH-flavin oxidoreductase frP SW:FRP_VIBHA (Q56691) (240 aa) fasta scores: E(): 0, 51.3% id in 240 aa; Orthologue of E. coli mdaA (NFSA_ECOLI); Fasta hit to NFSA_ECOLI (240 aa), 88% identity in 240 aa overlap.
     
 0.987
nemA
Similar to Escherichia coli N-ethylmaleimide reductase nemA SW:NEMA_ECOLI (P77258) (365 aa) fasta scores: E(): 0, 92.3% id in 365 aa, and to Enterobacter cloacae pentaerythritol tetranitrate reductase onR TR:P71278 (EMBL:U68759) (365 aa) fasta scores: E(): 0, 87.7% id in 365 aa.
  
 
 0.909
STY0621
Conserved hypothetical protein; Orthologue of E. coli ybdF (YBDF_ECOLI); Fasta hit to YBDF_ECOLI (122 aa), 74% identity in 121 aa overlap.
     
 0.625
STY3741
Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
    0.600
STY2976
HypA protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
     
 0.593
STY0975
Conserved hypothetical protein; Orthologue of E. coli YCAO_ECOLI; Fasta hit to YCAO_ECOLI (586 aa), 93% identity in 586 aa overlap.
  
  
 0.578
STY4224
Similar to Escherichia coli hypothetical ABC transporter ATP-binding protein YhiH SW:YHIH_ECOLI (P37624) (894 aa) fasta scores: E(): 0, 89.3% id in 896 aa, and to Escherichia coli hypothetical ABC transporter ATP-binding protein YbhF SW:YBHF_ECOLI (P75776) (578 aa) fasta scores: E(): 0, 35.9% id in 574 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein.
  
  
 0.578
frdB
Similar to Escherichia coli fumarate reductase iron-sulfur protein frdB SW:FRDB_ECOLI (P00364) (243 aa) fasta scores: E(): 0, 95.5% id in 243 aa, and to Proteus vulgaris fumarate reductase iron-sulfur protein frdB SW:FRDB_PROVU (P20921) (244 aa) fasta scores: E(): 0, 83.5% id in 242 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
      
 0.569
STY3510
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 95.4% id in 1486 aa and to Pseudomonas aeruginosa glutamate synthase large subunit GltB TR:P95456 (EMBL:U81261) (1482 aa) fasta scores: E(): 0, 60.9% id in 1476 aa.
     
 0.545
STY0622
Similar to Aquifex aeolicus transcriptional regulator acrr2 TR:O67927 (EMBL:AE000776) (192 aa) fasta scores: E(): 0.00033, 26.7% id in 101 aa, and to Bacillus megaterium transcriptional repressor Bm3r1 bm3r1 SW:BM3R_BACME (P43506) (192 aa) fasta scores: E(): 0.0035, 22.2% id in 189 aa.
     
 0.536
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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