STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY1090Conserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (150 aa)    
Predicted Functional Partners:
mukB
Cell division protein; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.
  
 
 
 0.960
STY0995
KicA protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
  
 
 
 0.914
STY0994
Killing factor KicB; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
  
 
 
 0.883
STY4062
Putative TetR-family transcriptional regulator; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
      
 0.814
STY3782
Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
  
   
 0.786
STY4238
Putative membrane protein; Similar to Escherichia coli hypothetical 10.3 kDa protein in ftsY-nikA intergenic region YhhL SW:YHHL_ECOLI (P37614) (89 aa) fasta scores: E(): 4.4e-32, 85.4% id in 89 aa. Predicted hydrophobic membrane spanning domains, integral membrane protein.
  
     0.774
trpR
Probable trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
  
     0.772
STY1953
Similar to Escherichia coli hypothetical 6.6 kDa protein in fadD-pabB intergenic region yoaH SW:YOAH_ECOLI (P76260) (59 aa) fasta scores: E(): 1.5e-18, 89.8% id in 59 aa, and to Salmonella typhimurium hypothetical protein in fadD-pabB intergenic region SW:YOAH_SALTY (P56505) (42 aa) fasta scores: E(): 4.7e-13, 100.0% id in 42 aa, and to Haemophilus influenzae hypothetical protein Hi1434.2 hi1434.2 SW:YOAH_HAEIN (P56507) (52 aa) fasta scores: E(): 1.2e-06, 65.1% id in 43 aa; Belongs to the UPF0181 family.
  
     0.767
STY1174
Conserved hypothetical protein; Orthologue of E. coli YCDY_ECOLI; Fasta hit to YCDY_ECOLI (184 aa), 86% identity in 184 aa overlap.
  
     0.764
STY3262
Conserved hypothetical protein; Orthologue of E. coli yggN (YGGN_ECOLI); Fasta hit to YGGN_ECOLI (239 aa), 88% identity in 239 aa overlap.
  
     0.755
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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