| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STY0432 | STY1270 | gene:17584457 | gene:17585234 | Phosphate regulon transcriptional regulatory protein PhoB; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 231 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 41% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 34% identity in 220 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 36% identity in 223 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 39% identity in 232 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 227 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 35% identity in 230 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 229 aa overlap; Fasta [...] | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | 0.833 |
| STY0432 | STY3507 | gene:17584457 | gene:17587358 | Phosphate regulon transcriptional regulatory protein PhoB; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 231 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 41% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 34% identity in 220 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 36% identity in 223 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 39% identity in 232 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 227 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 35% identity in 230 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 229 aa overlap; Fasta [...] | Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. | 0.858 |
| STY1270 | STY0432 | gene:17585234 | gene:17584457 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Phosphate regulon transcriptional regulatory protein PhoB; Fasta hit to TORR_ECOLI (230 aa), 34% identity in 231 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 41% identity in 224 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 34% identity in 220 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 36% identity in 223 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 39% identity in 232 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 34% identity in 227 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 35% identity in 230 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 39% identity in 229 aa overlap; Fasta [...] | 0.833 |
| STY1270 | STY1271 | gene:17585234 | gene:17585235 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | 0.999 |
| STY1270 | STY1647 | gene:17585234 | gene:17585582 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Similar to Staphylococcus aureus response regulator YycF yycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 8.8e-28, 37.6% id in 234 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 213 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 229 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 32% identity in 232 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 33% identity in 235 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 233 aa overlap; Orthologue of E. coli rstA (RSTA_ECOLI); Fasta hit [...] | 0.808 |
| STY1270 | STY1970 | gene:17585234 | gene:17585887 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Putative membrane protein; PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. | 0.830 |
| STY1270 | STY3507 | gene:17585234 | gene:17587358 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. | 0.846 |
| STY1270 | STY3812 | gene:17585234 | gene:17587676 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Two-component response regulatory protein; Fasta hit to TORR_ECOLI (230 aa), 32% identity in 233 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 39% identity in 226 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 36% identity in 232 aa overlap; Fasta hit to RSTA_ECOLI (242 aa), 34% identity in 233 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 37% identity in 231 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 40% identity in 230 aa overlap; Fasta hit to YGIX_ECOLI (219 aa), 36% identity in 228 aa overlap; Fasta hit to ARCA_ECOLI (238 aa), 34% identity in 228 aa overlap; Fasta hit to PHOB_ECO [...] | 0.768 |
| STY1270 | ompR | gene:17585234 | gene:17588125 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Two-component response regulator OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in regulating expression of the outer membrane porins OmpC and OmpF as well as other genes. Unlike E.coli or S.typhimurium both porins are expressed constitutively. Involved in regulation of the biosynthesis of Vi polysaccharide, a capsular antigen thought to be involved in the virulence of S.typhi. Vi antigen is synthesized at low NaCl concentrations (under 0.4 M). Binds to the promoter of both ompC and ompF (By similarity). | 0.846 |
| STY1270 | pmrA | gene:17585234 | gene:17588321 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Two-component response regulator; Similar to Salmonella typhimurium transcriptional regulatory protein PmrA or BasR SW:BASR_SALTY (P36556) (222 aa) fasta scores: E(): 0, 98.6% id in 222 aa, and to Escherichia coli transcriptional regulatory protein BasR SW:BASR_ECOLI (P30843) (222 aa) fasta scores: E(): 0, 90.1% id in 222 aa. | 0.952 |
| STY1270 | pmrD | gene:17585234 | gene:17586434 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Identical to Salmonella typhimurium polymyxin B resistance protein PmrD SW:PMRD_SALTY (P37589) (85 aa) fasta scores: E(): 0, 100.0% id in 84 aa; Orthologue of E. coli pmrD (PMRD_ECOLI); Fasta hit to PMRD_ECOLI (88 aa), 60% identity in 79 aa overlap. | 0.824 |
| STY1270 | ssrB | gene:17585234 | gene:17585666 | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | Putative two-component response regulator; Similar to Salmonella typhimurium SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 100.0% id in 193 aa, and to Streptococcus pneumoniae response regulator rr03 TR:Q9S1J7 (EMBL:AJ006393) (210 aa) fasta scores: E(): 1.4e-19, 34.5% id in 206 aa; Fasta hit to UHPA_ECOLI (196 aa), 33% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 32% identity in 198 aa overlap; Paralogue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 31% identity in 206 aa overlap. | 0.776 |
| STY1271 | STY1270 | gene:17585235 | gene:17585234 | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | 0.999 |
| STY1271 | STY1970 | gene:17585235 | gene:17585887 | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | Putative membrane protein; PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. | 0.827 |
| STY1271 | STY3507 | gene:17585235 | gene:17587358 | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. | 0.863 |
| STY1271 | pmrD | gene:17585235 | gene:17586434 | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | Identical to Salmonella typhimurium polymyxin B resistance protein PmrD SW:PMRD_SALTY (P37589) (85 aa) fasta scores: E(): 0, 100.0% id in 84 aa; Orthologue of E. coli pmrD (PMRD_ECOLI); Fasta hit to PMRD_ECOLI (88 aa), 60% identity in 79 aa overlap. | 0.828 |
| STY1271 | ssrB | gene:17585235 | gene:17585666 | Transcriptional regulatory protein PhoP, regulator of virulence determinants; Member of the two-component regulatory system PhoQ/PhoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. Promotes intramacrophage survival of S.typhi. Is required to enhance bacterial resistance to bile in the human intestinal cells. | Putative two-component response regulator; Similar to Salmonella typhimurium SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 100.0% id in 193 aa, and to Streptococcus pneumoniae response regulator rr03 TR:Q9S1J7 (EMBL:AJ006393) (210 aa) fasta scores: E(): 1.4e-19, 34.5% id in 206 aa; Fasta hit to UHPA_ECOLI (196 aa), 33% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 32% identity in 198 aa overlap; Paralogue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 31% identity in 206 aa overlap. | 0.821 |
| STY1647 | STY1270 | gene:17585582 | gene:17585234 | Similar to Staphylococcus aureus response regulator YycF yycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 8.8e-28, 37.6% id in 234 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 213 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 229 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 32% identity in 232 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 33% identity in 235 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 233 aa overlap; Orthologue of E. coli rstA (RSTA_ECOLI); Fasta hit [...] | Sensor protein PhoQ, regulator of virulence determinants; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phosph [...] | 0.808 |
| STY1647 | STY3507 | gene:17585582 | gene:17587358 | Similar to Staphylococcus aureus response regulator YycF yycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 8.8e-28, 37.6% id in 234 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 213 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 229 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 32% identity in 232 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 33% identity in 235 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 233 aa overlap; Orthologue of E. coli rstA (RSTA_ECOLI); Fasta hit [...] | Aerobic respiration control sensor protein; Orthologue of E. coli arcB (ARCB_ECOLI); Fasta hit to ARCB_ECOLI (776 aa), 94% identity in 778 aa overlap. | 0.830 |
| STY1647 | ssrB | gene:17585582 | gene:17585666 | Similar to Staphylococcus aureus response regulator YycF yycF TR:Q9XCM7 (EMBL:AF136709) (233 aa) fasta scores: E(): 8.8e-28, 37.6% id in 234 aa; Fasta hit to TORR_ECOLI (230 aa), 31% identity in 213 aa overlap; Fasta hit to BAER_ECOLI (240 aa), 34% identity in 229 aa overlap; Fasta hit to YLCA_ECOLI (227 aa), 32% identity in 232 aa overlap; Fasta hit to YEDW_ECOLI (239 aa), 34% identity in 233 aa overlap; Fasta hit to OMPR_ECOLI (239 aa), 33% identity in 235 aa overlap; Fasta hit to CPXR_ECOLI (232 aa), 37% identity in 233 aa overlap; Orthologue of E. coli rstA (RSTA_ECOLI); Fasta hit [...] | Putative two-component response regulator; Similar to Salmonella typhimurium SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 100.0% id in 193 aa, and to Streptococcus pneumoniae response regulator rr03 TR:Q9S1J7 (EMBL:AJ006393) (210 aa) fasta scores: E(): 1.4e-19, 34.5% id in 206 aa; Fasta hit to UHPA_ECOLI (196 aa), 33% identity in 202 aa overlap; Fasta hit to NARL_ECOLI (216 aa), 32% identity in 198 aa overlap; Paralogue of E. coli uvrY (UVRY_ECOLI); Fasta hit to UVRY_ECOLI (218 aa), 31% identity in 206 aa overlap. | 0.468 |
