STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pduGPduG protein; Similar to Salmonella enterica serovar Typhimurium protein PduG pduG TR:O31043 (EMBL:AF026270) (610 aa) fasta scores: E(): 0, 99.0% id in 610 aa and Klebsiella oxytoca diol dehydratase-reactivating factor large subunit ddrA TR:O68195 (EMBL:AF017781) (610 aa) fasta scores: E(): 0, 95.4% id in 608 aa. May be involved in removing inactive cofactor from the PduCDE dehydratase. Possibly also an adenosyltransferase (experimental). (610 aa)    
Predicted Functional Partners:
pduH
PduH protein; Similar to Salmonella enterica serovar Typhimurium protein PduH pduH TR:Q9XDN8 (EMBL:AF026270) (123 aa) fasta scores: E(): 0, 99.1% id in 111 aa and Klebsiella oxytoca diol dehydratase-reactivating factor small subunit ddrB TR:O68196 (EMBL:AF017781) (125 aa) fasta scores: E(): 0, 88.8% id in 116 aa. May be involved in removing inactive cofactor from the PduCDE dehydratase (in combination with pduG). A frameshift at codon 112 alters its C-terminus with respect to the homologues described above.
 
 
 0.997
pduC
Similar to Salmonella typhimurium glycerol dehydratase large subunit pduC SW:DHAB_SALTY (P37450) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa and Klebsiella oxytoca diol dehydratase alpha subunit pddA TR:Q59470 (EMBL:D45071) (554 aa) fasta scores: E(): 0, 99.6% id in 554 aa.
 
  
 0.984
pduB
Similar to Salmonella typhimurium propanediol utilization protein PduB pduB SW:PDUB_SALTY (P37449) (233 aa) fasta scores: E(): 0, 99.1% id in 233 aa. S. typhi pduB is probably not essential for propanediol catabolism (by similarity), but may be involved (cf. homologue in the eut operon). The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen.
 
  
 0.980
pduD
Similar to Salmonella typhimurium diol dehydratase medium subunit pduD TR:O31041 (EMBL:AF026270) (224 aa) fasta scores: E(): 0, 98.2% id in 224 aa and Klebsiella oxytoca diol dehydratase beta subunit pddB TR:Q59471 (EMBL:D45071) (224 aa) fasta scores: E(): 0, 95.1% id in 224 aa.
 
  
 0.979
pduO
Conserved hypothetical protein; Similar to Salmonella enterica serovar Typhimurium protein PduO pduO TR:Q9XDN2 (EMBL:AF026270) (337 aa) fasta scores: E(): 0, 92.6% id in 337 aa. N-terminal half is similar to many e.g. Clostridium pasteurianum hypothetical protein TR:O30452 (EMBL:AF006034) (173 aa) fasta scores: E(): 2.3e-21, 43.7% id in 167 aa and Citrobacter freundii hypothetical protein SW:YDHW_CITFR (P45515) (176 aa) fasta scores: E(): 3.2e-25, 47.9% id in 167 aa. C-terminal half is similar to many e.g. Clostridium pasteurianum hypothetical protein TR:O30453 (EMBL:AF006034) (143 aa) [...]
 
  
 0.962
pduE
Similar to Salmonella typhimurium diol dehydratase small subunit pduE TR:O31042 (EMBL:AF026270) (173 aa) fasta scores: E(): 0, 99.4% id in 173 aa, and to Klebsiella oxytoca diol dehydratase gamma pddC TR:Q59472 (EMBL:D45071) (173 aa) fasta scores: E(): 0, 96.5% id in 173 aa.
 
  
 0.960
STY0153
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 0.904
pduK
Putative propanediol utilization protein PduK; Similar to Salmonella enterica serovar Typhimurium protein PduK pduK TR:Q9XDN6 (EMBL:AF026270) (160 aa) fasta scores: E(): 0, 98.1% id in 160 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation which may protect the cell from toxic metabolites, or protect the dehydratase from oxygen.
 
  
 0.889
pduP
Putative CoA-dependent proprionaldehyde dehydrogenase; Similar to Salmonella enterica serovar Typhimurium protein PduP pduP TR:Q9XDN1 (EMBL:AF026270) (464 aa) fasta scores: E(): 0, 99.1% id in 464 aa and Salmonella typhimurium ethanolamine utilization protein EutE eutE SW:EUTE_SALTY (P41793) (467 aa) fasta scores: E(): 0, 45.7% id in 473 aa; Paralogue of E. coli eutE (EUTE_ECOLI); Fasta hit to EUTE_ECOLI (467 aa), 45% identity in 470 aa overlap.
 
  
 0.873
pduJ
Putative propanediol utilization protein PduJ; Similar to Salmonella enterica serovar Typhimurium protein PduJ pduJ TR:Q9XDN7 (EMBL:AF026270) (91 aa) fasta scores: E(): 4.2e-31, 100.0% id in 91 aa, Salmonella typhimurium propanediol utilization protein PduA pduA SW:PDUA_SALTY (P37448) (97 aa) fasta scores: E(): 6.7e-24, 84.9% id in 86 aa and Salmonella typhimurium ethanolamine utilization protein EutM precursor eutM or cchA SW:EUTM_SALTY (P41791) (96 aa) fasta scores: E(): 4.1e-18, 64.4% id in 87 aa. The Salmonella enterica homologue has been implicated in polyhedral body formation whi [...]
 
  
 0.869
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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