STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY2429Putative DNA-binding protein. (129 aa)    
Predicted Functional Partners:
STY2430
Putative L-serine dehydratase; Fasta hit to SDHM_ECOLI (455 aa), 50% identity in 452 aa overlap; Fasta hit to TDCG_ECOLI (454 aa), 51% identity in 450 aa overlap; Paralogue of E. coli sdaA (SDHL_ECOLI); Fasta hit to SDHL_ECOLI (454 aa), 49% identity in 453 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family.
       0.835
STY0605
Putative membrane protein; No database matches. Contains 10 putative transmembrane domains.
  
     0.770
STY0767
Similar to Bacillus subtilis hypothetical 39.8 kDa protein yveR TR:P71057 (EMBL:Z71928) (344 aa) fasta scores: E(): 0.0012, 24.1% id in 228 aa.
  
     0.742
STY1395
Invasin-like protein; Similar to Yersinia pseudotuberculosis invasin SW:INVA_YERPS (P11922) (985 aa) fasta scores: E(): 0, 30.3% id in 534 aa, and to Salmonella typhi invasin-like SivH sivH TR:AAF65573 (EMBL:AF247160) (626 aa) fasta scores: E(): 7.9e-32, 33.0% id in 379 aa, and to Escherichia coli hypothetical 47.0 kDa protein in chac-narl intergenic region ychO SW:YCHO_ECOLI (P39165; P46124; P76022) (417 aa) fasta scores: E(): 6.5e-30, 30.5% id in 377 aa.
  
     0.741
STY4128
Hypothetical protein; Unknown function.
  
     0.736
stpA
Tyrosine phosphatase (associated with virulence); Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity).
  
     0.728
STY4458
Large repetitive protein; Similar to Synechocystis sp. hypothetical 308.8 kDa protein slr0364 TR:Q55582 (EMBL:D63999) (3029 aa) fasta scores: E(): 0, 27.9% id in 2953 aa. Database searches show that the product of this CDS shares >90% aa identity with the previously sequenced Salmonella typhimurium SPI-4 hypothetical proteins: TR:O85315 (EMBL:AF060869), TR:O85316 (EMBL:AF060869), TR:O85317 (EMBL:AF060869), TR:O85318 (EMBL:AF060869), TR:O85319 (EMBL:AF060869), TR:O85320 (EMBL:AF060869), TR:O85321 (EMBL:AF060869). The product of this CDS is composed of multiple degenerate repeats. In add [...]
  
     0.724
STY2690
Hypothetical protein; Similar to Salmonella typhimurium hypothetical protein SW:YFE1_SALTY (Q9ZFU6) (263 aa) fasta scores: E(): 0, 91.3% id in 264 aa. Contains a C-terminal extension with respect to the Salmonella typhimurium homologue.
  
     0.721
STY4459
Large repetitive protein; Similar to Synechocystis sp. hypothetical 308.8 kDa protein slr0364 TR:Q55582 (EMBL:D63999) (3029 aa) fasta scores:E(): 0, 26.2% id in 2291 aa. Also similar to Salmonella typhimurium SPI-4 hypothetical proteins: TR:O85324 (EMBL:AF060869) (1512 aa) fasta scores: E(): 0, 97.6% id in 1464 aa and TR:O85325 (EMBL:AF060869) (463 aa) fasta scores: E(): 0, 97.4% id in 463 aa. Note product of this CDS is composed of multiple degenerate repeats and is significantly similar to the upstream CDS STY4458 fasta scores: E(): 0 33.24% identity in 2118 aa overlap.
  
     0.714
STY4453
Putative integral membrane protein; Similar to the C-terminus of Salmonella typhimurium hypothetical protein SPI4_A TR:O85311 (EMBL:AF060869) (524 aa) fasta scores: E(): 0, 95.4% id in 307 aa. Also similar to Salmonella typhimurium hypothetical protein SPI4_B TR:O85312 (EMBL:AF060869) (121 aa) fasta scores: E(): 0, 98.3% id in 121 aa. Contains multiple possible membrane spanning hydrophobic domains including a possible N-terminal signal sequence.
  
     0.713
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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