node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
STY0588 | STY1692 | gene:17584604 | gene:17585627 | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.636 |
STY0588 | STY1759 | gene:17584604 | gene:17585693 | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative membrane protein; Similar to Escherichia coli hypothetical 39.8 kDa protein in lpp-arod intergenic region ydiK SW:YDIK_ECOLI (P77175) (370 aa) fasta scores: E(): 0, 88.9% id in 370 aa, and to Streptomyces coelicolor integral membrane protein scf6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 6.8e-08, 26.0% id in 362 aa. | 0.817 |
STY0588 | STY2738 | gene:17584604 | gene:17586633 | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | 0.648 |
STY0588 | STY2812 | gene:17584604 | gene:17586702 | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.870 |
STY1344 | STY2738 | gene:17585304 | gene:17586633 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | 0.639 |
STY1344 | STY2739 | gene:17585304 | gene:17586634 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.953 |
STY1344 | STY2812 | gene:17585304 | gene:17586702 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Phosphoribosylformylglycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.737 |
STY1344 | STY4061 | gene:17585304 | gene:17587904 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.998 |
STY1344 | pyrB | gene:17585304 | gene:17588621 | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Similar to Salmonella typhimurium aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_SALTY (P08420) (309 aa) fasta scores: E(): 0, 98.4% id in 310 aa, and to Escherichia coli aspartate carbamoyltransferase catalytic chain PyrB SW:PYRB_ECOLI (P00479) (310 aa) fasta scores: E(): 0, 95.2% id in 310 aa; Fasta hit to OTC2_ECOLI (333 aa), 32% identity in 298 aa overlap; Fasta hit to OTC1_ECOLI (333 aa), 32% identity in 295 aa overlap. | 0.968 |
STY1692 | STY0588 | gene:17585627 | gene:17584604 | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.636 |
STY1692 | STY1759 | gene:17585627 | gene:17585693 | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Putative membrane protein; Similar to Escherichia coli hypothetical 39.8 kDa protein in lpp-arod intergenic region ydiK SW:YDIK_ECOLI (P77175) (370 aa) fasta scores: E(): 0, 88.9% id in 370 aa, and to Streptomyces coelicolor integral membrane protein scf6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 6.8e-08, 26.0% id in 362 aa. | 0.812 |
STY1692 | STY2738 | gene:17585627 | gene:17586633 | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | 0.611 |
STY1692 | STY3513 | gene:17585627 | gene:17587363 | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | Cytosine permease; Similar to Escherichia coli cytosine permease codB SW:CODB_ECOLI (P25525) (419 aa) fasta scores: E(): 0, 82.5% id in 416 aa. | 0.561 |
STY1759 | STY0588 | gene:17585693 | gene:17584604 | Putative membrane protein; Similar to Escherichia coli hypothetical 39.8 kDa protein in lpp-arod intergenic region ydiK SW:YDIK_ECOLI (P77175) (370 aa) fasta scores: E(): 0, 88.9% id in 370 aa, and to Streptomyces coelicolor integral membrane protein scf6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 6.8e-08, 26.0% id in 362 aa. | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.817 |
STY1759 | STY1692 | gene:17585693 | gene:17585627 | Putative membrane protein; Similar to Escherichia coli hypothetical 39.8 kDa protein in lpp-arod intergenic region ydiK SW:YDIK_ECOLI (P77175) (370 aa) fasta scores: E(): 0, 88.9% id in 370 aa, and to Streptomyces coelicolor integral membrane protein scf6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 6.8e-08, 26.0% id in 362 aa. | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. | 0.812 |
STY1759 | STY2738 | gene:17585693 | gene:17586633 | Putative membrane protein; Similar to Escherichia coli hypothetical 39.8 kDa protein in lpp-arod intergenic region ydiK SW:YDIK_ECOLI (P77175) (370 aa) fasta scores: E(): 0, 88.9% id in 370 aa, and to Streptomyces coelicolor integral membrane protein scf6.09 TR:Q9RJL9 (EMBL:AL121849) (363 aa) fasta scores: E(): 6.8e-08, 26.0% id in 362 aa. | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | 0.812 |
STY2737 | STY2738 | gene:17586632 | gene:17586633 | Conserved hypothetical protein; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | 0.661 |
STY2737 | STY2739 | gene:17586632 | gene:17586634 | Conserved hypothetical protein; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.451 |
STY2738 | STY0588 | gene:17586633 | gene:17584604 | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | FolD bifunctional protein [includes: methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.648 |
STY2738 | STY1344 | gene:17586633 | gene:17585304 | Uracil permease (uracil transporter); Fasta hit to YCDG_ECOLI (464 aa), 36% identity in 425 aa overlap; Orthologue of E. coli uraA (URAA_ECOLI); Fasta hit to URAA_ECOLI (429 aa), 95% identity in 425 aa overlap. | orotidine-5'-P decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.639 |