STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STY4487Conserved hypothetical protein; Similar to Escherichia coli PhnB protein SW:PHNB_ECOLI (P16681) (147 aa) fasta scores: E(): 0, 83.4% id in 145 aa, and to Lactococcus lactis hypothetical 16.9 kDa protein TR:O32784 (EMBL:X92946) (150 aa) fasta scores: E(): 3.4e-07, 28.9% id in 152 aa. (147 aa)    
Predicted Functional Partners:
STY4488
Conserved hypothetical protein; Similar to Escherichia coli PhnA protein SW:PHNA_ECOLI (P16680) (111 aa) fasta scores: E(): 0, 96.4% id in 111 aa, and to Neisseria meningitidis PhnA protein NMB0037 TR:AAF40508 (EMBL:AE002362) (109 aa) fasta scores: E(): 8.4e-27, 68.2% id in 110 aa.
     
 0.930
STY4486
Putative acetyltransferase; Similar to Escherichia coli PhnO protein SW:PHNO_ECOLI (P16691) (144 aa) fasta scores: E(): 0, 78.5% id in 144 aa, and to Streptomyces coelicolor hypothetical 16.7 kDa protein SCH24.35C TR:Q9X8U9 (EMBL:AL049826) (150 aa) fasta scores: E(): 4.9e-10, 33.1% id in 142 aa.
 
  
 0.923
phnR
Probable regulator of 2-aminoethylphosphonate uptake and metabolism operon; Previously sequenced as Salmonella typhimurium phnr TR:P96061 (EMBL:U69493) (239 aa) fasta scores: E(): 0, 100.0% id in 239 aa, and to Escherichia coli hypothetical transcriptional regulator in glnA-rbn intergenic region yihL SW:YIHL_ECOLI (P32133) (236 aa) fasta scores: E(): 4.7e-23, 33.0% id in 224 aa; Paralogue of E. coli YIHL_ECOLI; Fasta hit to YIHL_ECOLI (236 aa), 33% identity in 225 aa overlap.
   
  
 0.816
nadR
Conserved hypothetical transcriptional regulator; Bifunctional protein. DNA binding, contains helix-turn-helix. Transporter, interacts with NcuC transporting NMN into the cell. Similar to Salmonella typhimurium transcriptional regulator NadR SW:NADR_SALTY (P24518) (409 aa) fasta scores: E(): 0, 98.8% id in 410 aa, and to Escherichia coli transcriptional regulator NadR SW:NADR_ECOLI (P27278; P76819) (410 aa) fasta scores: E(): 0, 94.6% id in 409 aa.
   
    0.792
STY1426
Hypothetical protein; No significant database matches.
  
    0.516
STY0447
Conserved hypothetical protein; Similar to N-terminus of Mycobacterium tuberculosis hypothetical 27.6 kDa protein rv0911 or mtcy21c12.05 TR:O05903 (EMBL:Z95210) (257 aa) fasta scores: E(): 3.3e-05, 30.8% id in 117 aa, and to N-terminus of Streptomyces griseus orfd TR:Q54242 (EMBL:D45246) (270 aa) fasta scores: E(): 0.0069, 29.4% id in 119 aa.
 
  
 0.491
cobB
Putative regulatory protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
  
    0.431
yodD
Similar to Escherichia coli hypothetical protein yodD SW:YODD_ECOLI (P76328) (75 aa) fasta scores: E(): 8.4e-26, 92.0% id in 75 aa.
   
    0.410
Your Current Organism:
Salmonella enterica Typhi
NCBI taxonomy Id: 220341
Other names: S. enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi CT18, Salmonella enterica subsp. enterica serovar Typhi str. CT18, Salmonella enterica subsp. enterica serovar Typhi strain CT18, Salmonella typhi CT18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.